Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

abstract：:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the i...

journal_title：Immunity

authors： Coffman RL,Sher A,Seder RA

更新日期：2010-10-29 00:00:00

abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

journal_title：Immunity

authors： Evavold CL,Kagan JC

更新日期：2019-10-15 00:00:00

abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

journal_title：Immunity

authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

更新日期：2020-02-18 00:00:00

abstract：:T cell receptor (TCR)-mediated cytoskeletal reorganization is considered to be actin-related protein (Arp) 2/3 complex dependent. We therefore examined the requirement for Arp2/3- and formin-dependent F-actin nucleation during T cell activation. We demonstrated that without Arp2/3-mediated actin nucleation, stimulated...

journal_title：Immunity

authors： Gomez TS,Kumar K,Medeiros RB,Shimizu Y,Leibson PJ,Billadeau DD

更新日期：2007-02-01 00:00:00

abstract：:Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologou...

journal_title：Immunity

authors： Fraser KA,Schenkel JM,Jameson SC,Vezys V,Masopust D

更新日期：2013-07-25 00:00:00

abstract：:Tumor necrosis factor receptor (TNFR) superfamily members can induce a context-dependent apoptosis or cell activation. However, the mechanisms by which these opposing programs are selected remain unclear. We show that in T cells, TNFR2 (TNFRSF1B) signaling is dramatically affected by the intracellular mediator RIP, a ...

journal_title：Immunity

authors： Pimentel-Muiños FX,Seed B

更新日期：1999-12-01 00:00:00

abstract：:The intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria monocytogenes induced a robust intestinal CD8 T cell response and blocking e...

journal_title：Immunity

authors： Sheridan BS,Pham QM,Lee YT,Cauley LS,Puddington L,Lefrançois L

更新日期：2014-05-15 00:00:00

abstract：:NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...

journal_title：Immunity

authors： Brydges SD,Mueller JL,McGeough MD,Pena CA,Misaghi A,Gandhi C,Putnam CD,Boyle DL,Firestein GS,Horner AA,Soroosh P,Watford WT,O'Shea JJ,Kastner DL,Hoffman HM

更新日期：2009-06-19 00:00:00

abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...

journal_title：Immunity

authors： Nguyen HN,Noss EH,Mizoguchi F,Huppertz C,Wei KS,Watts GFM,Brenner MB

更新日期：2017-02-21 00:00:00

abstract：:Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were an...

journal_title：Immunity

authors： Morel L,Rudofsky UH,Longmate JA,Schiffenbauer J,Wakeland EK

更新日期：1994-06-01 00:00:00

abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

journal_title：Immunity

authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

更新日期：2002-08-01 00:00:00

abstract：:Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...

journal_title：Immunity

authors： Guo C,Xie S,Chi Z,Zhang J,Liu Y,Zhang L,Zheng M,Zhang X,Xia D,Ke Y,Lu L,Wang D

更新日期：2016-10-18 00:00:00

abstract：:Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at induction of experi...

journal_title：Immunity

authors： McGinley AM,Sutton CE,Edwards SC,Leane CM,DeCourcey J,Teijeiro A,Hamilton JA,Boon L,Djouder N,Mills KHG

更新日期：2020-02-18 00:00:00

abstract：:Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...

journal_title：Immunity

authors： Afonina IS,Müller C,Martin SJ,Beyaert R

更新日期：2015-06-16 00:00:00

abstract：:We and others have defined a transcriptional silencer critical for the proper expression of the CD4 gene at all stages of T cell development. In this report, we use biochemical techniques to identify three different factor-binding sites within the CD4 silencer, denoted sites I, II, and III. Using transgenic analyses, ...

journal_title：Immunity

authors： Duncan DD,Adlam M,Siu G

更新日期：1996-03-01 00:00:00

abstract：:Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...

journal_title：Immunity

authors： Konkel JE,Zhang D,Zanvit P,Chia C,Zangarle-Murray T,Jin W,Wang S,Chen W

更新日期：2017-04-18 00:00:00

abstract：:In this issue of Immunity, Jiang et al. (2011) provide evidence that the CD8 coreceptor is recruited to the T cell receptor (TCR) complex after initial TCR triggering where it stabilizes the TCR-peptide-major histocompatibility complex interaction. ...

journal_title：Immunity

authors： van der Merwe PA,Cordoba SP

更新日期：2011-01-28 00:00:00

abstract：:Superantigens (SAGs) activate T cells by simultaneously binding the Vbeta domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Valpha regions among SAG-reactive T cells has suggested that the TCR alpha chain may modulate the level of activation through an int...

journal_title：Immunity

authors： Andersen PS,Lavoie PM,Sékaly RP,Churchill H,Kranz DM,Schlievert PM,Karjalainen K,Mariuzza RA

更新日期：1999-04-01 00:00:00

abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...

journal_title：Immunity

authors： Delgoffe GM,Bettini ML,Vignali DA

更新日期：2012-11-16 00:00:00

abstract：:Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...

journal_title：Immunity

authors： Schultze JL,Beyer M

更新日期：2016-01-19 00:00:00

abstract：:In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...

journal_title：Immunity

authors： Greene TT,Labarta-Bajo L,Zuñiga EI

更新日期：2018-08-21 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

journal_title：Immunity

authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

更新日期：2012-12-14 00:00:00

abstract：:While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...

journal_title：Immunity

authors： Ortiz M,Wine JW,Lohrey N,Ruscetti FW,Spence SE,Keller JR

更新日期：1999-02-01 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...

journal_title：Immunity

authors： Lindeman GJ,Adams JM,Cory S,Harris AW

更新日期：1994-09-01 00:00:00

abstract：:Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...

journal_title：Immunity

authors： van Unen V,Li N,Molendijk I,Temurhan M,Höllt T,van der Meulen-de Jong AE,Verspaget HW,Mearin ML,Mulder CJ,van Bergen J,Lelieveldt BP,Koning F

更新日期：2016-05-17 00:00:00

abstract：:Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The developmental and functional relationship between individual subsets of monocytes and those of macrophages has not been fully elucidated, although Ly6C(+)CCR2(+...

journal_title：Immunity

authors： Egawa M,Mukai K,Yoshikawa S,Iki M,Mukaida N,Kawano Y,Minegishi Y,Karasuyama H

更新日期：2013-03-21 00:00:00

abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

journal_title：Immunity

authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

更新日期：2007-12-01 00:00:00

abstract：:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...

journal_title：Immunity

authors： Lambrecht BN,Hammad H,Fahy JV

更新日期：2019-04-16 00:00:00

abstract：:Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, w...

journal_title：Immunity

authors： Ahern PP,Schiering C,Buonocore S,McGeachy MJ,Cua DJ,Maloy KJ,Powrie F

更新日期：2010-08-27 00:00:00