Immune-cell lineage commitment: translation from mice to humans.

abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

journal_title：Immunity

authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

更新日期：2012-12-14 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Natural killer (NK) cells show some features of adaptive immunity but have not been studied at the clonal level. Here, we used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activatin...

journal_title：Immunity

authors： Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR

更新日期：2019-06-18 00:00:00

abstract：:Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...

journal_title：Immunity

authors： Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S

更新日期：2017-05-16 00:00:00

abstract：:Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associ...

journal_title：Immunity

authors： Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS

更新日期：2018-12-18 00:00:00

abstract：:Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...

journal_title：Immunity

authors： Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

更新日期：2016-07-19 00:00:00

abstract：:The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...

journal_title：Immunity

authors： Klein U,Dalla-Favera R

更新日期：2007-05-01 00:00:00

abstract：:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...

journal_title：Immunity

authors： Lindeman GJ,Adams JM,Cory S,Harris AW

更新日期：1994-09-01 00:00:00

abstract：:The mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFkappaB and IRFs and the induction of interferons in response to viral infection. In vitro studies have also suggested that MAVS is required for interferon induction by cytosolic DNA, but the in vivo evidence is lacking. By generating MAV...

journal_title：Immunity

authors： Sun Q,Sun L,Liu HH,Chen X,Seth RB,Forman J,Chen ZJ

更新日期：2006-05-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

journal_title：Immunity

authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

更新日期：2020-11-17 00:00:00

abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

journal_title：Immunity

authors： Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

更新日期：2002-04-01 00:00:00

abstract：:The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...

journal_title：Immunity

authors： Chen C,Huang X,Atakilit A,Zhu QS,Corey SJ,Sheppard D

更新日期：2006-12-01 00:00:00

abstract：:Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...

journal_title：Immunity

authors： Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

更新日期：2018-01-16 00:00:00

abstract：:Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...

journal_title：Immunity

authors： Yang S,Wang B,Humphries F,Hogan AE,O'Shea D,Moynagh PN

更新日期：2014-12-18 00:00:00

abstract：:The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...

journal_title：Immunity

authors： Ezekiel UR,Engler P,Stern D,Storb U

更新日期：1995-04-01 00:00:00

abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...

journal_title：Immunity

authors： Crotty S

更新日期：2014-10-16 00:00:00

abstract：:During development, discrete cell fates often result from variation in the intensity of a particular signal. The mechanisms underlying these seemingly analog-to-digital switches are not understood. In developing T lymphocytes, low-intensity signals through the antigen receptor result in positive selection while more i...

journal_title：Immunity

authors： Neilson JR,Winslow MM,Hur EM,Crabtree GR

更新日期：2004-03-01 00:00:00

abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

journal_title：Immunity

authors： Postat J,Olekhnovitch R,Lemaître F,Bousso P

更新日期：2018-10-16 00:00:00

abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...

journal_title：Immunity

authors： Smith TJ,Ducharme LA,Shaw SK,Parker CM,Brenner MB,Kilshaw PJ,Weis JH

更新日期：1994-08-01 00:00:00

abstract：:Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...

journal_title：Immunity

authors： Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

更新日期：1998-11-01 00:00:00

abstract：:Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...

journal_title：Immunity

authors： Cronan MR,Beerman RW,Rosenberg AF,Saelens JW,Johnson MG,Oehlers SH,Sisk DM,Jurcic Smith KL,Medvitz NA,Miller SE,Trinh LA,Fraser SE,Madden JF,Turner J,Stout JE,Lee S,Tobin DM

更新日期：2016-10-18 00:00:00

abstract：:Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...

journal_title：Immunity

authors： O'Neil LJ,Kaplan MJ

更新日期：2019-09-17 00:00:00

abstract：:The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...

journal_title：Immunity

authors： Sun M,Kee BL

更新日期：2017-09-19 00:00:00

abstract：:The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, wh...

journal_title：Immunity

authors： Miyao T,Floess S,Setoguchi R,Luche H,Fehling HJ,Waldmann H,Huehn J,Hori S

更新日期：2012-02-24 00:00:00

abstract：:Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...

journal_title：Immunity

authors： Wang Y,Ning X,Gao P,Wu S,Sha M,Lv M,Zhou X,Gao J,Fang R,Meng G,Su X,Jiang Z

更新日期：2017-03-21 00:00:00

abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...

journal_title：Immunity

authors： Beura LK,Masopust D

更新日期：2015-03-17 00:00:00

abstract：:T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...

journal_title：Immunity

authors： Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS

更新日期：1996-06-01 00:00:00

abstract：:The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution ...

journal_title：Immunity

authors： Mallevaey T,Clarke AJ,Scott-Browne JP,Young MH,Roisman LC,Pellicci DG,Patel O,Vivian JP,Matsuda JL,McCluskey J,Godfrey DI,Marrack P,Rossjohn J,Gapin L

更新日期：2011-03-25 00:00:00

abstract：:The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....

journal_title：Immunity

authors： Chai Q,Onder L,Scandella E,Gil-Cruz C,Perez-Shibayama C,Cupovic J,Danuser R,Sparwasser T,Luther SA,Thiel V,Rülicke T,Stein JV,Hehlgans T,Ludewig B

更新日期：2013-05-23 00:00:00

abstract：:A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...

journal_title：Immunity

authors： Shrikant P,Khoruts A,Mescher MF

更新日期：1999-10-01 00:00:00