Abstract:
:Natural killer (NK) cells show some features of adaptive immunity but have not been studied at the clonal level. Here, we used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activating receptor Ly49H. Clonal expansion of single NK cells varied substantially, and this variation could not be attributed to the additional presence or absence of inhibitory Ly49 receptors. Instead, single-cell-derived variability correlated with distinct surface expression levels of Ly49H itself. Ly49Hhi NK cell clones maintained higher Ly49H expression and expanded more than their Ly49Hlo counterparts in response to MCMV. Thus, akin to adaptive processes shaping an antigen-specific T cell receptor (TCR) repertoire, the Ly49H+ NK cell population adapts to MCMV infection. This process relies on the clonal maintenance of distinct Ly49H expression levels, generating a repertoire of individual NK cells outfitted with distinct reactivity to MCMV.
journal_name
Immunityjournal_title
Immunityauthors
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VRdoi
10.1016/j.immuni.2019.04.015subject
Has Abstractpub_date
2019-06-18 00:00:00pages
1391-1400.e4issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(19)30195-5journal_volume
50pub_type
评论,杂志文章相关文献
IMMUNITY文献大全abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80249-6
更新日期:1996-04-01 00:00:00
abstract::T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.02.013
更新日期:2012-04-20 00:00:00
abstract::HLA-DM removes CLIP and other loosely bound peptides from MHC class II molecules. The crystal structures of class II molecules and of HLA-DM have not permitted identification of their interaction sites. Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly mutagenized DR3 alph...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00051-0
更新日期:2000-10-01 00:00:00
abstract::The intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria monocytogenes induced a robust intestinal CD8 T cell response and blocking e...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.03.007
更新日期:2014-05-15 00:00:00
abstract::Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.014
更新日期:2016-10-18 00:00:00
abstract::Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00174-2
更新日期:2003-07-01 00:00:00
abstract::Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.08.012
更新日期:2010-09-24 00:00:00
abstract::A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor ce...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80457-4
更新日期:1998-01-01 00:00:00
abstract::Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.12.013
更新日期:2017-01-17 00:00:00
abstract::In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2006.07.006
更新日期:2006-07-01 00:00:00
abstract::C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80320-9
更新日期:1996-09-01 00:00:00
abstract::Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.11.016
更新日期:2010-11-24 00:00:00
abstract::Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.02.011
更新日期:2017-03-21 00:00:00
abstract::The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.03.011
更新日期:2006-05-01 00:00:00
abstract::The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.05.005
更新日期:2007-05-01 00:00:00
abstract::Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.03.014
更新日期:2014-06-19 00:00:00
abstract::Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.02.004
更新日期:2006-03-01 00:00:00
abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.02.005
更新日期:2009-04-17 00:00:00
abstract::To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80090-4
更新日期:1999-08-01 00:00:00
abstract::Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.08.017
更新日期:2006-10-01 00:00:00
abstract::Control of integrin-mediated adhesion and migration by chemokines plays a critical role in B cell development, differentiation, and function; however, the underlying signaling mechanisms are poorly defined. Here we show that the chemokine SDF-1 induced activation of Bruton's tyrosine kinase (Btk) and that integrin-med...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.11.012
更新日期:2007-01-01 00:00:00
abstract::T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.07.009
更新日期:2009-10-16 00:00:00
abstract::The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.04.010
更新日期:2015-05-19 00:00:00
abstract::Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.07.005
更新日期:2004-08-01 00:00:00
abstract::Upon TCR engagement, naive CD4 T cells differentiate toward the Th1 or Th2 phenotype. IL-4, acting through Stat6, plays a major role in Th2 differentiation; IL-2 has also been reported to be essential. Here, we report that retroviral (RV)-mediated expression of a constitutively active Stat5A mutant (STAT5A1*6) can ful...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00292-9
更新日期:2003-11-01 00:00:00
abstract::Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2013.07.017
更新日期:2013-08-22 00:00:00
abstract::Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within m...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90076-4
更新日期:1995-01-01 00:00:00
abstract::Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that granzyme B initiates caspase processing but cannot fully process procaspase-3 in intact Jurkat T leukemia or NT2 neuronal cells. Rather, the release from mitochondria of proapoptotic mediators ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00050-5
更新日期:2003-03-01 00:00:00
abstract::Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.08.015
更新日期:2011-10-28 00:00:00
abstract::T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.10.014
更新日期:2017-11-21 00:00:00