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T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

Abstract：

:Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4-Cre induced chronic inflammation of the intestine despite the importance of PDK1 in T cell activation. Analysis of colonic intraepithelial lymphocytes of PDK1-deficient mice revealed markedly increased CD8α(+) T cell receptor (TCR)γδ(+) T cells, including an interleukin-17 (IL-17)-expressing population. TCRγδ(+) T cells were responsible for the inflammatory colitis as shown by the fact that deletion of Tcrd abolished spontaneous colitis in the PDK1-deficient mice. This dysregulation of intestinal TCRγδ(+) T cells was attributable to a reduction in the number and functional capacity of PDK1-deficient T regulatory (Treg) cells. Adoptive transfer of wild-type Treg cells abrogated the spontaneous activation and proliferation of intestinal TCRγδ(+) T cells observed in PDK1-deficient mice and prevented the development of colitis. Therefore, suppression of intestinal TCRγδ(+) T cells by Treg cells maintains enteric immune tolerance.

journal_name

Immunity

journal_title

Immunity

authors

Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S

doi

10.1016/j.immuni.2010.10.014

subject

Has Abstract

pub_date

2010-11-24 00:00:00

pages

791-803

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(10)00400-0

journal_volume

33

pub_type

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