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Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

Abstract：

:Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyrophosphate antigens in the absence of other accessory cells but, under such conditions, required T cell-T cell contact. Recognition required neither the expression of classical MHC class I, MHC class II, or CD1a, CD1b, and CD1c molecules, nor MHC class I or class II peptide loading pathways. Fixed accessory cells also presented the prenyl pyrophosphate antigens to gamma delta T cells. Thus, in contrast with the presentation of conventional peptide antigens, protein antigens, and superantigens to alpha beta T cells, prenyl pyrophosphate antigens are presented to gamma delta T cells through a novel extracellular pathway that does not require antigen uptake, antigen processing, or MHC class I or class II expression. This pathway allows for the rapid recognition of bacteria by gamma delta T cells and suggests that gamma delta T cells play a role in the early response to bacterial infection.

journal_name

Immunity

journal_title

Immunity

authors

Morita CT,Beckman EM,Bukowski JF,Tanaka Y,Band H,Bloom BR,Golan DE,Brenner MB

doi

10.1016/1074-7613(95)90178-7

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

495-507

issue

4

eissn

1074-7613

issn

1097-4180

pii

1074-7613(95)90178-7

journal_volume

3

pub_type

杂志文章

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