Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

journal_title：Immunity

authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

更新日期：2020-09-15 00:00:00

abstract：:Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

journal_title：Immunity

authors： Monahan A,Kleino A,Silverman N

更新日期：2016-11-15 00:00:00

abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

journal_title：Immunity

authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

更新日期：2017-12-19 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these Vgamma2Vdelta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induc...

journal_title：Immunity

authors： Das H,Groh V,Kuijl C,Sugita M,Morita CT,Spies T,Bukowski JF

更新日期：2001-07-01 00:00:00

abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

journal_title：Immunity

authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

更新日期：2009-06-19 00:00:00

abstract：:microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...

journal_title：Immunity

authors： Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

更新日期：2007-12-01 00:00:00

abstract：:PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

journal_title：Immunity

authors： Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

更新日期：2018-06-19 00:00:00

abstract：:The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...

journal_title：Immunity

authors： Hart A,Melet F,Grossfeld P,Chien K,Jones C,Tunnacliffe A,Favier R,Bernstein A

更新日期：2000-08-01 00:00:00

abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

journal_title：Immunity

authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

更新日期：2000-05-01 00:00:00

abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

journal_title：Immunity

authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

更新日期：2005-02-01 00:00:00

abstract：:Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appropriate immune response. To initiate responses to highly disparate challenges, DCs have diversified into multiple phenotypically, anatomically, and functionally distinct cell types. As a res...

journal_title：Immunity

authors： Nutt SL,Chopin M

更新日期：2020-06-16 00:00:00

abstract：:A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitme...

journal_title：Immunity

authors： Chou RC,Kim ND,Sadik CD,Seung E,Lan Y,Byrne MH,Haribabu B,Iwakura Y,Luster AD

更新日期：2010-08-27 00:00:00

abstract：:MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cel...

journal_title：Immunity

authors： Belver L,de Yébenes VG,Ramiro AR

更新日期：2010-11-24 00:00:00

abstract：:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex...

journal_title：Immunity

authors： Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

更新日期：1997-05-01 00:00:00

abstract：:The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...

journal_title：Immunity

authors： Chen C,Huang X,Atakilit A,Zhu QS,Corey SJ,Sheppard D

更新日期：2006-12-01 00:00:00

abstract：:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

journal_title：Immunity

authors： Shin S,Cherry S

更新日期：2017-10-17 00:00:00

abstract：:Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg...

journal_title：Immunity

authors： Ruan Q,Kameswaran V,Tone Y,Li L,Liou HC,Greene MI,Tone M,Chen YH

更新日期：2009-12-18 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...

journal_title：Immunity

authors： Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

更新日期：2012-10-19 00:00:00

abstract：:The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, and a lack of new mouse mutants. By using N-ethyl-N-nitrosourea (ENU) mutagene...

journal_title：Immunity

authors： Yu P,Constien R,Dear N,Katan M,Hanke P,Bunney TD,Kunder S,Quintanilla-Martinez L,Huffstadt U,Schröder A,Jones NP,Peters T,Fuchs H,de Angelis MH,Nehls M,Grosse J,Wabnitz P,Meyer TP,Yasuda K,Schiemann M,Schneider-Fr

更新日期：2005-04-01 00:00:00

abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

journal_title：Immunity

authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

更新日期：2004-12-01 00:00:00

abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

journal_title：Immunity

authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

更新日期：2011-10-28 00:00:00

abstract：:We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...

journal_title：Immunity

authors： Thorsson V,Gibbs DL,Brown SD,Wolf D,Bortone DS,Ou Yang TH,Porta-Pardo E,Gao GF,Plaisier CL,Eddy JA,Ziv E,Culhane AC,Paull EO,Sivakumar IKA,Gentles AJ,Malhotra R,Farshidfar F,Colaprico A,Parker JS,Mose LE,Vo NS,L

更新日期：2018-04-17 00:00:00

abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

journal_title：Immunity

authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

更新日期：1995-03-01 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...

journal_title：Immunity

authors： Colgan J,Asmal M,Neagu M,Yu B,Schneidkraut J,Lee Y,Sokolskaja E,Andreotti A,Luban J

更新日期：2004-08-01 00:00:00

abstract：:Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

journal_title：Immunity

authors： Schwartzberg PL

更新日期：2007-02-01 00:00:00

abstract：:CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy....

journal_title：Immunity

authors： Topalian SL,Sharpe AH

更新日期：2014-11-20 00:00:00

abstract：:The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...

journal_title：Immunity

authors： Hikosaka Y,Nitta T,Ohigashi I,Yano K,Ishimaru N,Hayashi Y,Matsumoto M,Matsuo K,Penninger JM,Takayanagi H,Yokota Y,Yamada H,Yoshikai Y,Inoue J,Akiyama T,Takahama Y

更新日期：2008-09-19 00:00:00