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Balance and imbalance in the immune system: life on the edge.

Abstract：

:CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.

journal_name

Immunity

journal_title

Immunity

authors

Topalian SL,Sharpe AH

doi

10.1016/j.immuni.2014.11.005

subject

Has Abstract

pub_date

2014-11-20 00:00:00

pages

682-4

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(14)00400-2

journal_volume

41

pub_type

评论,杂志文章

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