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The Cytokines of Asthma.

Abstract：

:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Here, we review the cytokine networks driving asthma, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic. We discuss established and emerging paradigms in the context of the growing appreciation of disease heterogeneity and argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.

journal_name

Immunity

journal_title

Immunity

authors

Lambrecht BN,Hammad H,Fahy JV

doi

10.1016/j.immuni.2019.03.018

subject

Has Abstract

pub_date

2019-04-16 00:00:00

pages

975-991

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(19)30135-9

journal_volume

50

pub_type

杂志文章,评审

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