Abstract:
:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumulation and control of chronic lymphocytic choriomeningitis virus (LCMV). We found that type I interferon (IFN-I) induced TNFSF ligands GITRL, 4-1BBL, OX40L, and CD70 predominantly on monocyte-derived APCs and CD80 and CD86 predominantly on classical dendritic cells (cDCs). Mice with hypofunctional GITRL in Lyz2+ cells had decreased LCMV-specific CD4+ T cell accumulation and increased viral load. GITR signals in CD4+ T cells occurred after priming to upregulate OX40, CD25, and chemokine receptor CX3CR1. Thus IFN-I (signal 3) induced a post-priming checkpoint (signal 4) for CD4+ T cell accumulation, revealing a division of labor between cDCs and monocyte-derived APCs in regulating T cell expansion.
journal_name
Immunityjournal_title
Immunityauthors
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts THdoi
10.1016/j.immuni.2017.10.014subject
Has Abstractpub_date
2017-11-21 00:00:00pages
943-958.e9issue
5eissn
1074-7613issn
1097-4180pii
S1074-7613(17)30469-7journal_volume
47pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.04.004
更新日期:2011-04-22 00:00:00
abstract::HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80332-5
更新日期:1997-03-01 00:00:00
abstract::Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80245-9
更新日期:1997-01-01 00:00:00
abstract::The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.06.003
更新日期:2006-06-01 00:00:00
abstract::Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80637-8
更新日期:1998-10-01 00:00:00
abstract::Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.08.012
更新日期:2010-09-24 00:00:00
abstract::The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.08.019
更新日期:2017-09-19 00:00:00
abstract::Caspases are intracellular proteases that mediate mammalian cell apoptosis. Caspase-1 (Casp-1) is a unique caspase because it activates the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Shigella flexneri, the etiological agent of bacillary dysentery, induces macrophage apoptosis, which requires Casp-1 an...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80209-5
更新日期:2000-05-01 00:00:00
abstract::Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE). The increased bioavailability of type I IFN contributes to peripheral tolerance breakdown through the activation of immature myeloid dendritic cells (mDCs). IFN-matured mDCs activate autoreacti...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.08.010
更新日期:2006-09-01 00:00:00
abstract::We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80425-2
更新日期:1997-02-01 00:00:00
abstract::TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antig...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.07.019
更新日期:2004-09-01 00:00:00
abstract::B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.03.020
更新日期:2020-05-19 00:00:00
abstract::As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.11.017
更新日期:2019-01-15 00:00:00
abstract::Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2005.11.010
更新日期:2006-01-01 00:00:00
abstract::Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.03.015
更新日期:2016-04-19 00:00:00
abstract::Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected t...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.04.023
更新日期:2016-05-17 00:00:00
abstract::Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.08.005
更新日期:2016-08-16 00:00:00
abstract::Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the consequence of terminating signals that activate V(H) genes for recombina...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00030-x
更新日期:2003-02-01 00:00:00
abstract::Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90034-5
更新日期:1994-11-01 00:00:00
abstract::The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.013
更新日期:2018-06-19 00:00:00
abstract::Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00174-2
更新日期:2003-07-01 00:00:00
abstract::The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00017-0
更新日期:2000-08-01 00:00:00
abstract::Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2020.04.004
更新日期:2020-07-14 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.06.016
更新日期:2014-08-21 00:00:00
abstract::Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.019
更新日期:2008-06-01 00:00:00
abstract::Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyroph...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90178-7
更新日期:1995-10-01 00:00:00
abstract::Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.10.007
更新日期:2006-11-01 00:00:00
abstract::Inflammation mediated by antibody-antigen complexes contributes to autoimmune diseases. Mice deficient in the common Fcgamma-chain are protected from IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and FcR-bearing macrophages, and mast cells have been assigned primary roles in these proce...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.013
更新日期:2008-06-01 00:00:00
abstract::Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.08.007
更新日期:2015-09-15 00:00:00
abstract::Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.05.018
更新日期:2007-07-01 00:00:00