Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

journal_title：Immunity

authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

更新日期：2016-06-21 00:00:00

abstract：:Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which geneti...

journal_title：Immunity

authors： Wakeland EK,Liu K,Graham RR,Behrens TW

更新日期：2001-09-01 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

journal_title：Immunity

authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

更新日期：2017-12-19 00:00:00

abstract：:Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...

journal_title：Immunity

authors： Nimmerjahn F,Ravetch JV

更新日期：2006-01-01 00:00:00

abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...

journal_title：Immunity

authors： Thomas MD,Kremer CS,Ravichandran KS,Rajewsky K,Bender TP

更新日期：2005-09-01 00:00:00

abstract：:Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...

journal_title：Immunity

authors： Van Opdenbosch N,Lamkanfi M

更新日期：2019-06-18 00:00:00

abstract：:Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

journal_title：Immunity

authors： Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

更新日期：2000-07-01 00:00:00

abstract：:Cdc42 and WASP are critical regulators of actin polymerization whose function during T cell signaling is poorly understood. Using a novel reagent that specifically detects Cdc42-GTP in fixed cells, we found that activated Cdc42 localizes to the T cell:APC contact site in an antigen-dependent manner. TCR signaling alon...

journal_title：Immunity

authors： Cannon JL,Labno CM,Bosco G,Seth A,McGavin MH,Siminovitch KA,Rosen MK,Burkhardt JK

更新日期：2001-08-01 00:00:00

abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

journal_title：Immunity

authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

更新日期：2020-09-15 00:00:00

abstract：:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...

journal_title：Immunity

authors： Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FE

更新日期：2009-03-20 00:00:00

abstract：:Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...

journal_title：Immunity

authors： Rinkenberger JL,Wallin JJ,Johnson KW,Koshland ME

更新日期：1996-10-01 00:00:00

abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...

journal_title：Immunity

authors： Crotty S

更新日期：2014-10-16 00:00:00

abstract：:Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these Vgamma2Vdelta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induc...

journal_title：Immunity

authors： Das H,Groh V,Kuijl C,Sugita M,Morita CT,Spies T,Bukowski JF

更新日期：2001-07-01 00:00:00

abstract：:PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

journal_title：Immunity

authors： Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

更新日期：2018-06-19 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

journal_title：Immunity

authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

更新日期：2013-09-19 00:00:00

abstract：:The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...

journal_title：Immunity

authors： Klein U,Dalla-Favera R

更新日期：2007-05-01 00:00:00

abstract：:Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

journal_title：Immunity

authors： Monahan A,Kleino A,Silverman N

更新日期：2016-11-15 00:00:00

abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...

journal_title：Immunity

authors： Naujokas MF,Arneson LS,Fineschi B,Peterson ME,Sitterding S,Hammond AT,Reilly C,Lo D,Miller J

更新日期：1995-09-01 00:00:00

abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...

journal_title：Immunity

authors： Rodewald HR,Feyerabend TB

更新日期：2012-07-27 00:00:00

abstract：:Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under...

journal_title：Immunity

authors： Coxon A,Cullere X,Knight S,Sethi S,Wakelin MW,Stavrakis G,Luscinskas FW,Mayadas TN

更新日期：2001-06-01 00:00:00

abstract：:Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...

journal_title：Immunity

authors： Selin LK,Welsh RM

更新日期：2004-01-01 00:00:00

abstract：:In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...

journal_title：Immunity

authors： Greene TT,Labarta-Bajo L,Zuñiga EI

更新日期：2018-08-21 00:00:00

abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...

journal_title：Immunity

authors： Amanat F,Krammer F

更新日期：2020-04-14 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

journal_title：Immunity

authors： Agudo J,Brown BD

更新日期：2016-03-15 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...

journal_title：Immunity

authors： Escobar TM,Kanellopoulou C,Kugler DG,Kilaru G,Nguyen CK,Nagarajan V,Bhairavabhotla RK,Northrup D,Zahr R,Burr P,Liu X,Zhao K,Sher A,Jankovic D,Zhu J,Muljo SA

更新日期：2014-06-19 00:00:00

abstract：:T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...

journal_title：Immunity

authors： Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

更新日期：2009-10-16 00:00:00

abstract：:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...

journal_title：Immunity

authors： Lindeman GJ,Adams JM,Cory S,Harris AW

更新日期：1994-09-01 00:00:00

abstract：:Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...

journal_title：Immunity

authors： Radomska HS,Shen CP,Kadesch T,Eckhardt LA

更新日期：1994-11-01 00:00:00