Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus.

Abstract:

:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses.

journal_name

Immunity

journal_title

Immunity

authors

Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FE

doi

10.1016/j.immuni.2009.01.006

subject

Has Abstract

pub_date

2009-03-20 00:00:00

pages

421-33

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(09)00101-0

journal_volume

30

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Proteolysis in MHC class II antigen presentation: who's in charge?

    abstract::Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the c...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/s1074-7613(00)80176-4

    authors: Villadangos JA,Ploegh HL

    更新日期:2000-03-01 00:00:00

  • The LTi cell, an immunologic chameleon.

    abstract::Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2010.11.016

    authors: Strober W

    更新日期:2010-11-24 00:00:00

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

    abstract::Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90025-x

    authors: Wagtmann N,Biassoni R,Cantoni C,Verdiani S,Malnati MS,Vitale M,Bottino C,Moretta L,Moretta A,Long EO

    更新日期:1995-05-01 00:00:00

  • GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

    abstract::The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.03.022

    authors: Dougan M,Dranoff G,Dougan SK

    更新日期:2019-04-16 00:00:00

  • Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

    abstract::CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2015.02.003

    authors: Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ

    更新日期:2015-03-17 00:00:00

  • Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.

    abstract::Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/s1074-7613(03)00303-0

    authors: Niiro H,Clark EA

    更新日期:2003-11-01 00:00:00

  • TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

    abstract::Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.03.004

    authors: Angiari S,Donnarumma T,Rossi B,Dusi S,Pietronigro E,Zenaro E,Della Bianca V,Toffali L,Piacentino G,Budui S,Rennert P,Xiao S,Laudanna C,Casasnovas JM,Kuchroo VK,Constantin G

    更新日期:2014-04-17 00:00:00

  • "Hands-on" regulation of B cell development by the transcription factor Pax5.

    abstract::The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2007.07.001

    authors: Hagman J,Lukin K

    更新日期:2007-07-01 00:00:00

  • Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

    abstract::PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.04.031

    authors: Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

    更新日期:2018-06-19 00:00:00

  • It's a Phase That EBF1 Is Going Through.

    abstract::EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.11.013

    authors: Kee BL

    更新日期:2020-12-15 00:00:00

  • Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells.

    abstract::Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we analyzed the costimulatory requirements for the induction of Th9 cells, and demonstrated that Notch pathway ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.01.020

    authors: Elyaman W,Bassil R,Bradshaw EM,Orent W,Lahoud Y,Zhu B,Radtke F,Yagita H,Khoury SJ

    更新日期:2012-04-20 00:00:00

  • Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo.

    abstract::Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliv...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80613-5

    authors: Combadière B,Reis e Sousa C,Trageser C,Zheng LX,Kim CR,Lenardo MJ

    更新日期:1998-09-01 00:00:00

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

    abstract::The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2004.10.014

    authors: Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

    更新日期:2004-12-01 00:00:00

  • Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.

    abstract::The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.07.008

    authors: Hou Y,Liang H,Rao E,Zheng W,Huang X,Deng L,Zhang Y,Yu X,Xu M,Mauceri H,Arina A,Weichselbaum RR,Fu YX

    更新日期:2018-09-18 00:00:00

  • Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals.

    abstract::The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.04.023

    authors: Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

    更新日期:2020-06-16 00:00:00

  • CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.

    abstract::The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence. Here we demonstrate, using mice with a targeted deletion in CXCL5, that CXCL5 bound erythrocyte DARC and impaired its chemokin...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.07.009

    authors: Mei J,Liu Y,Dai N,Favara M,Greene T,Jeyaseelan S,Poncz M,Lee JS,Worthen GS

    更新日期:2010-07-23 00:00:00

  • Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells.

    abstract::PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL cha...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80107-7

    authors: Yamagami T,ten Boekel E,Andersson J,Rolink A,Melchers F

    更新日期:1999-09-01 00:00:00

  • The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

    abstract::The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.05.022

    authors: Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

    更新日期:2019-08-20 00:00:00

  • The Cytokines of Asthma.

    abstract::Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.03.018

    authors: Lambrecht BN,Hammad H,Fahy JV

    更新日期:2019-04-16 00:00:00

  • T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment.

    abstract::Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80296-4

    authors: Wilson A,de Villartay JP,MacDonald HR

    更新日期:1996-01-01 00:00:00

  • A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells.

    abstract::Differentiation of naive T cells into mature Th2 cells is associated with the appearance of a complex pattern of DNase I hypersensitive (DH) sites within the IL-4/IL-13 cytokine gene cluster. We show here that targeted deletion of an inducible DH site, V(A), and the adjacent conserved DH site V (CNS-2) selectively com...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00334-5

    authors: Solymar DC,Agarwal S,Bassing CH,Alt FW,Rao A

    更新日期:2002-07-01 00:00:00

  • Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.

    abstract::Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well defined. To identify the global regulatory networks controlling antigen presentation, we employed genome-wide screening in human di...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.11.002

    authors: Dersh D,Phelan JD,Gumina ME,Wang B,Arbuckle JH,Holly J,Kishton RJ,Markowitz TE,Seedhom MO,Fridlyand N,Wright GW,Huang DW,Ceribelli M,Thomas CJ,Lack JB,Restifo NP,Kristie TM,Staudt LM,Yewdell JW

    更新日期:2021-01-12 00:00:00

  • The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.

    abstract::B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells th...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.07.023

    authors: Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa T

    更新日期:2016-09-20 00:00:00

  • Aiolos: an ungrateful member of the Ikaros family.

    abstract::Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.immuni.2007.03.003

    authors: Kioussis D

    更新日期:2007-03-01 00:00:00

  • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.

    abstract::Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.002

    authors: Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

    更新日期:2013-08-22 00:00:00

  • Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.

    abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80249-6

    authors: Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

    更新日期:1996-04-01 00:00:00

  • Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.

    abstract::Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80082-5

    authors: Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DH

    更新日期:1999-07-01 00:00:00

  • Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

    abstract::Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2015.06.011

    authors: Vanden Berghe T,Hulpiau P,Martens L,Vandenbroucke RE,Van Wonterghem E,Perry SW,Bruggeman I,Divert T,Choi SM,Vuylsteke M,Shestopalov VI,Libert C,Vandenabeele P

    更新日期:2015-07-21 00:00:00

  • Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65.

    abstract::During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80130-2

    authors: Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

    更新日期:1999-11-01 00:00:00

  • Macrophage activation and polarization: nomenclature and experimental guidelines.

    abstract::Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.06.008

    authors: Murray PJ,Allen JE,Biswas SK,Fisher EA,Gilroy DW,Goerdt S,Gordon S,Hamilton JA,Ivashkiv LB,Lawrence T,Locati M,Mantovani A,Martinez FO,Mege JL,Mosser DM,Natoli G,Saeij JP,Schultze JL,Shirey KA,Sica A,Suttles J,U

    更新日期:2014-07-17 00:00:00