Abstract:
:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses.
journal_name
Immunityjournal_title
Immunityauthors
Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FEdoi
10.1016/j.immuni.2009.01.006subject
Has Abstractpub_date
2009-03-20 00:00:00pages
421-33issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(09)00101-0journal_volume
30pub_type
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