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B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mouse strain.

Abstract：

:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes that promote lymphocyte survival or proliferation. Bitransgenic myc/max 41 mice developed pre-B cell lymphoma. An accompanying massive granulocytosis unexpectedly proved to be clonally derived from the pre-B lymphoma cells. These observations suggest that B lymphopoiesis in max 41 mice has been diverted to granulocyte production. Since neither cell type expressed the transgene, this novel lymphomyeloid deviation probably reflects insertional alteration of a hematopoietic regulatory gene.

journal_name

Immunity

journal_title

Immunity

authors

Lindeman GJ,Adams JM,Cory S,Harris AW

doi

10.1016/1074-7613(94)90094-9

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

517-27

issue

6

eissn

1074-7613

issn

1097-4180

pii

1074-7613(94)90094-9

journal_volume

1

pub_type

杂志文章

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