Caspases in Cell Death, Inflammation, and Disease.

abstract：:The regulation of actin dynamics is pivotal for cellular processes such as cell adhesion, migration, and phagocytosis and thus is crucial for neutrophils to fulfill their roles in innate immunity. Many factors have been implicated in signal-induced actin polymerization, but the essential nature of the potential negati...

journal_title：Immunity

authors： Sakai J,Li J,Subramanian KK,Mondal S,Bajrami B,Hattori H,Jia Y,Dickinson BC,Zhong J,Ye K,Chang CJ,Ho YS,Zhou J,Luo HR

更新日期：2012-12-14 00:00:00

abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...

journal_title：Immunity

authors： Kiani A,Viola JP,Lichtman AH,Rao A

更新日期：1997-12-01 00:00:00

abstract：:Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to mediate this effect. Expression of the 21 kDa US6 glycoprotein in human cytomegalovirus-infected cells correlates with the inhibition of peptide tran...

journal_title：Immunity

authors： Hengel H,Koopmann JO,Flohr T,Muranyi W,Goulmy E,Hämmerling GJ,Koszinowski UH,Momburg F

更新日期：1997-05-01 00:00:00

abstract：:Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling E...

journal_title：Immunity

authors：

更新日期：2019-12-17 00:00:00

abstract：:Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune ...

journal_title：Immunity

authors： Galon J,Angell HK,Bedognetti D,Marincola FM

更新日期：2013-07-25 00:00:00

abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...

journal_title：Immunity

authors： Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

更新日期：2015-09-15 00:00:00

abstract：:Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

journal_title：Immunity

authors： Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

更新日期：2008-07-18 00:00:00

abstract：:Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquir...

journal_title：Immunity

authors： Cheng LE,Hartmann K,Roers A,Krummel MF,Locksley RM

更新日期：2013-01-24 00:00:00

abstract：:When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially i...

journal_title：Immunity

authors： Lazear HM,Nice TJ,Diamond MS

更新日期：2015-07-21 00:00:00

abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

journal_title：Immunity

authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

更新日期：2001-11-01 00:00:00

abstract：:Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...

journal_title：Immunity

authors： Radomska HS,Shen CP,Kadesch T,Eckhardt LA

更新日期：1994-11-01 00:00:00

abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...

journal_title：Immunity

authors： Stone EL,Pepper M,Katayama CD,Kerdiles YM,Lai CY,Emslie E,Lin YC,Yang E,Goldrath AW,Li MO,Cantrell DA,Hedrick SM

更新日期：2015-02-17 00:00:00

abstract：:Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

journal_title：Immunity

authors： Neuenhahn M,Busch DH

更新日期：2013-01-24 00:00:00

abstract：:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...

journal_title：Immunity

authors： Lambrecht BN,Hammad H,Fahy JV

更新日期：2019-04-16 00:00:00

abstract：:The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...

journal_title：Immunity

authors： Ezekiel UR,Engler P,Stern D,Storb U

更新日期：1995-04-01 00:00:00

abstract：:B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overa...

journal_title：Immunity

authors： Linsley PS,Greene JL,Brady W,Bajorath J,Ledbetter JA,Peach R

更新日期：1994-12-01 00:00:00

abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

journal_title：Immunity

authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

更新日期：2011-10-28 00:00:00

abstract：:HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...

journal_title：Immunity

authors： Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

更新日期：1997-03-01 00:00:00

abstract：:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infec...

journal_title：Immunity

authors： van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

更新日期：2011-07-22 00:00:00

abstract：:The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

journal_title：Immunity

authors： Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

更新日期：2019-08-20 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

journal_title：Immunity

authors： Agudo J,Brown BD

更新日期：2016-03-15 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...

journal_title：Immunity

authors： Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

更新日期：2012-10-19 00:00:00

abstract：:Aging results in increased myelopoiesis, which is linked to the increased incidence of myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibit immune regulatory function and sequester in bone...

journal_title：Immunity

authors： Pioli PD,Casero D,Montecino-Rodriguez E,Morrison SL,Dorshkind K

更新日期：2019-08-20 00:00:00

abstract：:Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

journal_title：Immunity

authors： van den Berg TK,van Bruggen R

更新日期：2015-10-20 00:00:00

abstract：:EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...

journal_title：Immunity

authors： Kee BL

更新日期：2020-12-15 00:00:00

abstract：:In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...

journal_title：Immunity

authors： Bluestone JA,Crellin N,Trotta E

更新日期：2015-05-19 00:00:00

abstract：:Murine natural killer cells selectively express members of the Ly49 family of class I MHC receptors; however, the molecular mechanism controlling probabilistic expression of Ly49 proteins has not been defined. A pair of overlapping, divergent promoters discovered in the Ly49g gene functions as a molecular switch that ...

journal_title：Immunity

authors： Saleh A,Davies GE,Pascal V,Wright PW,Hodge DL,Cho EH,Lockett SJ,Abshari M,Anderson SK

更新日期：2004-07-01 00:00:00

abstract：:Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The developmental and functional relationship between individual subsets of monocytes and those of macrophages has not been fully elucidated, although Ly6C(+)CCR2(+...

journal_title：Immunity

authors： Egawa M,Mukai K,Yoshikawa S,Iki M,Mukaida N,Kawano Y,Minegishi Y,Karasuyama H

更新日期：2013-03-21 00:00:00

abstract：:Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...

journal_title：Immunity

authors： Brenchley JM,Silvestri G,Douek DC

更新日期：2010-06-25 00:00:00

abstract：:The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets. ...

journal_title：Immunity

authors： Stephens GL,Shevach EM

更新日期：2007-09-01 00:00:00