Type I interferon in systemic lupus erythematosus and other autoimmune diseases.

abstract：:The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

journal_title：Immunity

authors： Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

更新日期：2013-11-14 00:00:00

abstract：:Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...

journal_title：Immunity

authors： Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S

更新日期：2017-05-16 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

journal_title：Immunity

authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

更新日期：2015-08-18 00:00:00

abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

journal_title：Immunity

authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

更新日期：2003-08-01 00:00:00

abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...

journal_title：Immunity

authors： Beura LK,Masopust D

更新日期：2015-03-17 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...

journal_title：Immunity

authors： Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN

更新日期：2014-08-21 00:00:00

abstract：:Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights a...

journal_title：Immunity

authors： Kunkel EJ,Butcher EC

更新日期：2002-01-01 00:00:00

abstract：:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...

journal_title：Immunity

authors： Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FE

更新日期：2009-03-20 00:00:00

abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

journal_title：Immunity

authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

更新日期：2020-06-16 00:00:00

abstract：:Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17 (IL-17) to secrete...

journal_title：Immunity

authors： Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S

更新日期：2018-06-19 00:00:00

abstract：:We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...

journal_title：Immunity

authors： Prigozy TI,Sieling PA,Clemens D,Stewart PL,Behar SM,Porcelli SA,Brenner MB,Modlin RL,Kronenberg M

更新日期：1997-02-01 00:00:00

abstract：:The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. H...

journal_title：Immunity

authors： Dykstra ML,Longnecker R,Pierce SK

更新日期：2001-01-01 00:00:00

abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

journal_title：Immunity

authors： Infantino S,Tarlinton DM

更新日期：2013-03-21 00:00:00

abstract：:The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the s...

journal_title：Immunity

authors： Ghosh HS,Cisse B,Bunin A,Lewis KL,Reizis B

更新日期：2010-12-14 00:00:00

abstract：:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

journal_title：Immunity

authors： Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

更新日期：2013-09-19 00:00:00

abstract：:Galactocerebrosides (GCs) represent a major class of glycolipids in the nervous system. Here, we show that mice lacking the key enzyme to generate GCs, UDP-galactose:ceramide galactosyltransferase (CGT(-/-)), exhibit severe postnatal atrophy of all lymphoid organs, owing to a maturational arrest before the pro-B/T cel...

journal_title：Immunity

authors： Katayama Y,Frenette PS

更新日期：2003-06-01 00:00:00

abstract：:Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The developmental and functional relationship between individual subsets of monocytes and those of macrophages has not been fully elucidated, although Ly6C(+)CCR2(+...

journal_title：Immunity

authors： Egawa M,Mukai K,Yoshikawa S,Iki M,Mukaida N,Kawano Y,Minegishi Y,Karasuyama H

更新日期：2013-03-21 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks ...

journal_title：Immunity

authors： Caldwell RG,Wilson JB,Anderson SJ,Longnecker R

更新日期：1998-09-01 00:00:00

abstract：:Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...

journal_title：Immunity

authors： Janetzki S,Britten CM,Kalos M,Levitsky HI,Maecker HT,Melief CJ,Old LJ,Romero P,Hoos A,Davis MM

更新日期：2009-10-16 00:00:00

abstract：:In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s). ...

journal_title：Immunity

authors： Motomura Y,Kobayashi T,Moro K

更新日期：2019-10-15 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is ...

journal_title：Immunity

authors： Biburger M,Aschermann S,Schwab I,Lux A,Albert H,Danzer H,Woigk M,Dudziak D,Nimmerjahn F

更新日期：2011-12-23 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4-Cre induced chronic inflammation of the intestine despite the importance of PDK1 in T cell activation. Analysis of colonic intraepit...

journal_title：Immunity

authors： Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S

更新日期：2010-11-24 00:00:00

abstract：:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...

journal_title：Immunity

authors： Sutkowski N,Conrad B,Thorley-Lawson DA,Huber BT

更新日期：2001-10-01 00:00:00

abstract：:The gut microbiota is a complex and plastic network of diverse organisms intricately connected with human physiology. Recent advances in profiling approaches of both the microbiota and the immune system now enable a deeper exploration of immunity-microbiota connections. An important next step is to elucidate a human-r...

journal_title：Immunity

authors： Spencer SP,Fragiadakis GK,Sonnenburg JL

更新日期：2019-08-20 00:00:00

abstract：:We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...

journal_title：Immunity

authors： Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

更新日期：2006-02-01 00:00:00

abstract：:Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...

journal_title：Immunity

authors： Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

更新日期：2016-07-19 00:00:00

abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...

journal_title：Immunity

authors： Rodewald HR,Feyerabend TB

更新日期：2012-07-27 00:00:00

abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

journal_title：Immunity

authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

更新日期：1998-08-01 00:00:00

abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

journal_title：Immunity

authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

更新日期：2017-01-17 00:00:00