Abstract:
:The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport. Mutant LMP2A that permits BCR signaling and raft translocation still blocks antigen trafficking, indicating independent control of these BCR functions. Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functions of the BCR by independent mechanisms.
journal_name
Immunityjournal_title
Immunityauthors
Dykstra ML,Longnecker R,Pierce SKdoi
10.1016/s1074-7613(01)00089-9keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
57-67issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(01)00089-9journal_volume
14pub_type
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