Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.

Abstract:

:The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport. Mutant LMP2A that permits BCR signaling and raft translocation still blocks antigen trafficking, indicating independent control of these BCR functions. Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functions of the BCR by independent mechanisms.

journal_name

Immunity

journal_title

Immunity

authors

Dykstra ML,Longnecker R,Pierce SK

doi

10.1016/s1074-7613(01)00089-9

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

57-67

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00089-9

journal_volume

14

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.

    abstract::We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and are highly susceptible to abscess formation by gram-positive bacteria. Arrested, morphologically atypical, Gr1(+)Mac1(+) myeloid cells expand with age in the bone marrow...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00501-0

    authors: Hock H,Hamblen MJ,Rooke HM,Traver D,Bronson RT,Cameron S,Orkin SH

    更新日期:2003-01-01 00:00:00

  • Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events.

    abstract::Most lineage marker-negative (Lin-)TdT+ cells from murine marrow lack CD34 but display c-kit at low density as well as IL-7Ralpha and Flk-2/Flt-3 receptors. Single cells with these characteristics generated CD45RA+CD19- as well as CD19+ lymphocytes in culture. CD45RA+CD19- marrow cells were resolved into three nonover...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80186-7

    authors: Tudor KS,Payne KJ,Yamashita Y,Kincade PW

    更新日期:2000-03-01 00:00:00

  • NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

    abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2011.03.026

    authors: Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

    更新日期:2011-06-24 00:00:00

  • Dendritic cells in vivo: a key target for a new vaccine science.

    abstract::Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.08.001

    authors: Steinman RM

    更新日期:2008-09-19 00:00:00

  • Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

    abstract::CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, althou...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.028

    authors: Gao Y,Nish SA,Jiang R,Hou L,Licona-Limón P,Weinstein JS,Zhao H,Medzhitov R

    更新日期:2013-10-17 00:00:00

  • The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

    abstract::To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00394-1

    authors: Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

    更新日期:2002-09-01 00:00:00

  • Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.

    abstract::Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.06.024

    authors: Andrews SF,Chambers MJ,Schramm CA,Plyler J,Raab JE,Kanekiyo M,Gillespie RA,Ransier A,Darko S,Hu J,Chen X,Yassine HM,Boyington JC,Crank MC,Chen GL,Coates E,Mascola JR,Douek DC,Graham BS,Ledgerwood JE,McDermott AB

    更新日期:2019-08-20 00:00:00

  • Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

    abstract::Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.07.017

    authors: Chan TD,Wood K,Hermes JR,Butt D,Jolly CJ,Basten A,Brink R

    更新日期:2012-11-16 00:00:00

  • Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

    abstract::Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless,...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2006.05.011

    authors: Broussard C,Fleischacker C,Horai R,Chetana M,Venegas AM,Sharp LL,Hedrick SM,Fowlkes BJ,Schwartzberg PL

    更新日期:2006-07-01 00:00:00

  • Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

    abstract::CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(03)00116-x

    authors: Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

    更新日期:2003-05-01 00:00:00

  • Balance and imbalance in the immune system: life on the edge.

    abstract::CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy....

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.11.005

    authors: Topalian SL,Sharpe AH

    更新日期:2014-11-20 00:00:00

  • Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

    abstract::Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00262-5

    authors: Kuhn JR,Poenie M

    更新日期:2002-01-01 00:00:00

  • The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

    abstract::NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of microRNAs (miRNAs). miR-29 expression was upregulated in human dendritic cells (DCs) in response to NOD2 signals, and miR-29 regulated the expression of multipl...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.035

    authors: Brain O,Owens BM,Pichulik T,Allan P,Khatamzas E,Leslie A,Steevels T,Sharma S,Mayer A,Catuneanu AM,Morton V,Sun MY,Jewell D,Coccia M,Harrison O,Maloy K,Schönefeldt S,Bornschein S,Liston A,Simmons A

    更新日期:2013-09-19 00:00:00

  • Toll signaling in flies and mammals: two sorts of MyD88.

    abstract::The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.04.001

    authors: Goto A,Imler JL

    更新日期:2012-04-20 00:00:00

  • The Miami Monkey: A Sunny Alternative to the Berlin Patient.

    abstract::Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2019.02.010

    authors: Liberatore RA,Ho DD

    更新日期:2019-03-19 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.10.011

    authors: Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期:2018-12-18 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract::Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.025

    authors: Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期:2013-09-19 00:00:00

  • TRAF3: uncovering the real but restricted role in human.

    abstract::In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2010.09.008

    authors: Bowie AG

    更新日期:2010-09-24 00:00:00

  • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.

    abstract::Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00279-0

    authors: Green EA,Choi Y,Flavell RA

    更新日期:2002-02-01 00:00:00

  • Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel.

    abstract::Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)00013-3

    authors: Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

    更新日期:2000-07-01 00:00:00

  • A Shocking Type of Communication.

    abstract::In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis....

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2018.12.004

    authors: Sallis BF,Fiebiger E

    更新日期:2018-12-18 00:00:00

  • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

    abstract::An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed I...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00324-2

    authors: Pflanz S,Timans JC,Cheung J,Rosales R,Kanzler H,Gilbert J,Hibbert L,Churakova T,Travis M,Vaisberg E,Blumenschein WM,Mattson JD,Wagner JL,To W,Zurawski S,McClanahan TK,Gorman DM,Bazan JF,de Waal Malefyt R,Rennick D,

    更新日期:2002-06-01 00:00:00

  • Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.

    abstract::The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.07.008

    authors: Hou Y,Liang H,Rao E,Zheng W,Huang X,Deng L,Zhang Y,Yu X,Xu M,Mauceri H,Arina A,Weichselbaum RR,Fu YX

    更新日期:2018-09-18 00:00:00

  • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

    abstract::Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.004

    authors: Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

    更新日期:2013-09-19 00:00:00

  • The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

    abstract::The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.10.013

    authors: Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

    更新日期:2013-11-14 00:00:00

  • Lnc'ing Id2 to ILC1.

    abstract::The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2017.08.019

    authors: Sun M,Kee BL

    更新日期:2017-09-19 00:00:00

  • Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.

    abstract::Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.02.012

    authors: Bantug GR,Fischer M,Grählert J,Balmer ML,Unterstab G,Develioglu L,Steiner R,Zhang L,Costa ASH,Gubser PM,Burgener AV,Sauder U,Löliger J,Belle R,Dimeloe S,Lötscher J,Jauch A,Recher M,Hönger G,Hall MN,Romero P,Frez

    更新日期:2018-03-20 00:00:00

  • Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes.

    abstract::Superantigens (SAGs) activate T cells by simultaneously binding the Vbeta domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Valpha regions among SAG-reactive T cells has suggested that the TCR alpha chain may modulate the level of activation through an int...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80047-3

    authors: Andersen PS,Lavoie PM,Sékaly RP,Churchill H,Kranz DM,Schlievert PM,Karjalainen K,Mariuzza RA

    更新日期:1999-04-01 00:00:00

  • Illuminating the black box of TNF action in tuberculous granulomas.

    abstract::TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2008.07.003

    authors: Miller EA,Ernst JD

    更新日期:2008-08-15 00:00:00

  • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.

    abstract::To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80090-4

    authors: Semerad CL,Poursine-Laurent J,Liu F,Link DC

    更新日期:1999-08-01 00:00:00