Pursuing Human-Relevant Gut Microbiota-Immune Interactions.

abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

journal_title：Immunity

authors： Evavold CL,Kagan JC

更新日期：2019-10-15 00:00:00

abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...

journal_title：Immunity

authors： Sugiyama T,Kohara H,Noda M,Nagasawa T

更新日期：2006-12-01 00:00:00

abstract：:The role of the center of the immunological synapse (the central supramolecular activation cluster or cSMAC) is controversial. One model suggests that the role of the cSMAC depends on antigen quality and can both enhance signaling and receptor downregulation, whereas a second model proposes that the sole function of t...

journal_title：Immunity

authors： Cemerski S,Das J,Giurisato E,Markiewicz MA,Allen PM,Chakraborty AK,Shaw AS

更新日期：2008-09-19 00:00:00

abstract：:In comparison to murine dendritic cells (DCs), less is known about the function of human DCs in tissues. Here, we analyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) DCs in determining the type of CD8(+) T cell immunity generated to live-attenuated influenza virus (LA...

journal_title：Immunity

authors： Yu CI,Becker C,Wang Y,Marches F,Helft J,Leboeuf M,Anguiano E,Pourpe S,Goller K,Pascual V,Banchereau J,Merad M,Palucka K

更新日期：2013-04-18 00:00:00

abstract：:The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) respo...

journal_title：Immunity

authors： Carroll EC,Jin L,Mori A,Muñoz-Wolf N,Oleszycka E,Moran HBT,Mansouri S,McEntee CP,Lambe E,Agger EM,Andersen P,Cunningham C,Hertzog P,Fitzgerald KA,Bowie AG,Lavelle EC

更新日期：2016-03-15 00:00:00

abstract：:Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...

journal_title：Immunity

authors： Blériot C,Dupuis T,Jouvion G,Eberl G,Disson O,Lecuit M

更新日期：2015-01-20 00:00:00

abstract：:The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted ...

journal_title：Immunity

authors： Gangadharan D,Lambolez F,Attinger A,Wang-Zhu Y,Sullivan BA,Cheroutre H

更新日期：2006-10-01 00:00:00

abstract：:The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...

journal_title：Immunity

authors： Zhou J,Peng H,Li K,Qu K,Wang B,Wu Y,Ye L,Dong Z,Wei H,Sun R,Tian Z

更新日期：2019-02-19 00:00:00

abstract：:Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...

journal_title：Immunity

authors： DeFranco AL

更新日期：2008-11-14 00:00:00

abstract：:Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...

journal_title：Immunity

authors： Brenchley JM,Silvestri G,Douek DC

更新日期：2010-06-25 00:00:00

abstract：:Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...

journal_title：Immunity

authors： Smith LK,Boukhaled GM,Condotta SA,Mazouz S,Guthmiller JJ,Vijay R,Butler NS,Bruneau J,Shoukry NH,Krawczyk CM,Richer MJ

更新日期：2018-02-20 00:00:00

abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

journal_title：Immunity

authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

更新日期：2020-06-16 00:00:00

abstract：:Appropriate priming of tolerogenic or effector immune responses is crucial for intestinal homeostasis. Recently in Nature, Esterházy et al. (2019) reveal how compartmentalization of lymphatic drainage to functionally distinct lymph nodes facilitates the simultaneous induction of tolerogenic and effector responses. ...

journal_title：Immunity

authors： Thomson CA,McCoy KD

更新日期：2019-07-16 00:00:00

abstract：:The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence. Here we demonstrate, using mice with a targeted deletion in CXCL5, that CXCL5 bound erythrocyte DARC and impaired its chemokin...

journal_title：Immunity

authors： Mei J,Liu Y,Dai N,Favara M,Greene T,Jeyaseelan S,Poncz M,Lee JS,Worthen GS

更新日期：2010-07-23 00:00:00

abstract：:The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

journal_title：Immunity

authors： Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

更新日期：2011-06-24 00:00:00

abstract：:Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

journal_title：Immunity

authors： Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

更新日期：2000-07-01 00:00:00

abstract：:The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we ...

journal_title：Immunity

authors： Kanneganti TD,Lamkanfi M,Núñez G

更新日期：2007-10-01 00:00:00

abstract：:T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...

journal_title：Immunity

authors： Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

更新日期：2009-10-16 00:00:00

abstract：:Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...

journal_title：Immunity

authors： Liu X,Nemeth DP,McKim DB,Zhu L,DiSabato DJ,Berdysz O,Gorantla G,Oliver B,Witcher KG,Wang Y,Negray CE,Vegesna RS,Sheridan JF,Godbout JP,Robson MJ,Blakely RD,Popovich PG,Bilbo SD,Quan N

更新日期：2019-02-19 00:00:00

abstract：:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...

journal_title：Immunity

authors： Ogasawara K,Hamerman JA,Ehrlich LR,Bour-Jordan H,Santamaria P,Bluestone JA,Lanier LL

更新日期：2004-06-01 00:00:00

abstract：:To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

journal_title：Immunity

authors： Semerad CL,Poursine-Laurent J,Liu F,Link DC

更新日期：1999-08-01 00:00:00

abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

journal_title：Immunity

authors： Gangloff M,Gay NJ

更新日期：2008-03-01 00:00:00

abstract：:Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...

journal_title：Immunity

authors： Pilli M,Arko-Mensah J,Ponpuak M,Roberts E,Master S,Mandell MA,Dupont N,Ornatowski W,Jiang S,Bradfute SB,Bruun JA,Hansen TE,Johansen T,Deretic V

更新日期：2012-08-24 00:00:00

abstract：:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infec...

journal_title：Immunity

authors： van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

更新日期：2011-07-22 00:00:00

abstract：:ZAP-70 and Syk are PTKs required for TCR and BCR function, respectively. Loss of the Syk PTK results in a nonfunctional BCR. We provide evidence here that ZAP-70 and Syk are functionally homologous in antigen receptor signaling by demonstrating that expression of ZAP-70 in Syk- B cells reconstitutes BCR function. Reco...

journal_title：Immunity

authors： Kong GH,Bu JY,Kurosaki T,Shaw AS,Chan AC

更新日期：1995-05-01 00:00:00

abstract：:In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...

journal_title：Immunity

authors： McKee AS,Munks MW,Marrack P

更新日期：2007-11-01 00:00:00

abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

journal_title：Immunity

authors： Postat J,Olekhnovitch R,Lemaître F,Bousso P

更新日期：2018-10-16 00:00:00

abstract：:Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...

journal_title：Immunity

authors： Radomska HS,Shen CP,Kadesch T,Eckhardt LA

更新日期：1994-11-01 00:00:00

abstract：:Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

journal_title：Immunity

authors： Schwartzberg PL

更新日期：2007-02-01 00:00:00

abstract：:We and others have defined a transcriptional silencer critical for the proper expression of the CD4 gene at all stages of T cell development. In this report, we use biochemical techniques to identify three different factor-binding sites within the CD4 silencer, denoted sites I, II, and III. Using transgenic analyses, ...

journal_title：Immunity

authors： Duncan DD,Adlam M,Siu G

更新日期：1996-03-01 00:00:00