Abstract:
:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in the CSF of patients with meningitis, and LBP-deficient mice failed to develop meningeal inflammation. LBP enhanced PCW-induced cell signaling and TNF-alpha release. LBP bound specifically to PCW multimers, indicating novel lipid-independent binding capability for LBP. We propose the iterative anionic groups along the glycan backbone of the cell wall are a crucial structure for recognition by LBP. Such a function for LBP expands its role to Gram-positive infections.
journal_name
Immunityjournal_title
Immunityauthors
Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RRdoi
10.1016/s1074-7613(03)00205-xkeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
269-79issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(03)00205-Xjournal_volume
19pub_type
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