Abstract:
:The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not preclude differentiation to TCR gamma delta + T cells. This is consistent with the view that an initial consequence of beta chain expression by early thymocytes is clonal expansion, increasing the size of the pool of useful precursors. This allows the proposal to be made that allelic exclusion may be a byproduct of cell cycle regulation during early thymocyte differentiation, which may in turn explain why the efficiency of allelic exclusion varies at different TCR or immunoglobulin loci.
journal_name
Immunityjournal_title
Immunityauthors
Dudley EC,Petrie HT,Shah LM,Owen MJ,Hayday ACdoi
10.1016/1074-7613(94)90102-3subject
Has Abstractpub_date
1994-05-01 00:00:00pages
83-93issue
2eissn
1074-7613issn
1097-4180pii
1074-7613(94)90102-3journal_volume
1pub_type
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