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Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Abstract：

:The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.

journal_name

Immunity

journal_title

Immunity

authors

Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

doi

10.1016/s1074-7613(02)00419-3

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

463-72

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00419-3

journal_volume

17

pub_type

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