当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

Abstract：

:Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

journal_name

Immunity

journal_title

Immunity

authors

Mueller YM,De Rosa SC,Hutton JA,Witek J,Roederer M,Altman JD,Katsikis PD

doi

10.1016/s1074-7613(01)00246-1

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

871-82

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00246-1

journal_volume

15

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.

    abstract：:The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.10.010

    authors： Rao RR,Li Q,Odunsi K,Shrikant PA

    更新日期：2010-01-29 00:00:00

  • Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

    abstract：:CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.02.003

    authors： Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ

    更新日期：2015-03-17 00:00:00

  • Murine M290 integrin expression modulated by mast cell activation.

    abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(94)90070-1

    authors： Smith TJ,Ducharme LA,Shaw SK,Parker CM,Brenner MB,Kilshaw PJ,Weis JH

    更新日期：1994-08-01 00:00:00

  • Necroptosis turns TNF lethal.

    abstract：:In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2011.12.004

    authors： Galluzzi L,Kroemer G

    更新日期：2011-12-23 00:00:00

  • Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids.

    abstract：:Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(94)90034-5

    authors： Radomska HS,Shen CP,Kadesch T,Eckhardt LA

    更新日期：1994-11-01 00:00:00

  • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells.

    abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.006

    authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

    更新日期：2009-06-19 00:00:00

  • The Birds, the Bees, and Innate Immunity.

    abstract：:The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.04.002

    authors： Barber GN

    更新日期：2017-04-18 00:00:00

  • The Cytokines of Asthma.

    abstract：:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.03.018

    authors： Lambrecht BN,Hammad H,Fahy JV

    更新日期：2019-04-16 00:00:00

  • The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

    abstract：:The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.07.016

    authors： Alvarez-Diaz S,Dillon CP,Lalaoui N,Tanzer MC,Rodriguez DA,Lin A,Lebois M,Hakem R,Josefsson EC,O'Reilly LA,Silke J,Alexander WS,Green DR,Strasser A

    更新日期：2016-09-20 00:00:00

  • Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting.

    abstract：:Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologou...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.07.003

    authors： Fraser KA,Schenkel JM,Jameson SC,Vezys V,Masopust D

    更新日期：2013-07-25 00:00:00

  • Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo.

    abstract：:Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliv...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80613-5

    authors： Combadière B,Reis e Sousa C,Trageser C,Zheng LX,Kim CR,Lenardo MJ

    更新日期：1998-09-01 00:00:00

  • HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

    abstract：:HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80332-5

    authors： Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

    更新日期：1997-03-01 00:00:00

  • Caspase-8: clipping off RIG-I signaling.

    abstract：:Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2011.03.011

    authors： Roth S,Ruland J

    更新日期：2011-03-25 00:00:00

  • Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

    abstract：:The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.03.012

    authors： Chai Q,Onder L,Scandella E,Gil-Cruz C,Perez-Shibayama C,Cupovic J,Danuser R,Sparwasser T,Luther SA,Thiel V,Rülicke T,Stein JV,Hehlgans T,Ludewig B

    更新日期：2013-05-23 00:00:00

  • Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.

    abstract：:Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2009.06.008

    authors： Colonna M

    更新日期：2009-07-17 00:00:00

  • NLRC3 puts the brakes on STING.

    abstract：:NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.02.007

    authors： Mangan MS,Latz E

    更新日期：2014-03-20 00:00:00

  • A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

    abstract：:mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their differentiation and survival. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.11.006

    authors： Alon R

    更新日期：2017-11-21 00:00:00

  • Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

    abstract：:Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.12.002

    authors： Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A

    更新日期：2011-12-23 00:00:00

  • Formin the way.

    abstract：:Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

    journal_title：Immunity

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.immuni.2007.02.007

    authors： Schwartzberg PL

    更新日期：2007-02-01 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract：:Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.011

    authors： Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期：2018-12-18 00:00:00

  • "Hands-on" regulation of B cell development by the transcription factor Pax5.

    abstract：:The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2007.07.001

    authors： Hagman J,Lukin K

    更新日期：2007-07-01 00:00:00

  • Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

    abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.10.012

    authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

    更新日期：2015-11-17 00:00:00

  • Nonprogressive and progressive primate immunodeficiency lentivirus infections.

    abstract：:Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2010.06.004

    authors： Brenchley JM,Silvestri G,Douek DC

    更新日期：2010-06-25 00:00:00

  • Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein.

    abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00226-6

    authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

    更新日期：2001-11-01 00:00:00

  • Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin.

    abstract：:The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple extracellular signals to transcriptional responses. The capacity of mIg to activate these MAP kinases is synergisticall...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80510-5

    authors： Tooze RM,Doody GM,Fearon DT

    更新日期：1997-07-01 00:00:00

  • Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

    abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.06.017

    authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

    更新日期：2017-07-18 00:00:00

  • Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.

    abstract：:Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2006.10.007

    authors： Watford WT,O'Shea JJ

    更新日期：2006-11-01 00:00:00

  • NKG2D blockade prevents autoimmune diabetes in NOD mice.

    abstract：:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.05.008

    authors： Ogasawara K,Hamerman JA,Ehrlich LR,Bour-Jordan H,Santamaria P,Bluestone JA,Lanier LL

    更新日期：2004-06-01 00:00:00

  • Aiolos: an ungrateful member of the Ikaros family.

    abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.immuni.2007.03.003

    authors： Kioussis D

    更新日期：2007-03-01 00:00:00

  • Foxp3+ regulatory T cells: selfishness under scrutiny.

    abstract：:The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.immuni.2007.08.008

    authors： Stephens GL,Shevach EM

    更新日期：2007-09-01 00:00:00