"Hands-on" regulation of B cell development by the transcription factor Pax5.

abstract：:Aging results in increased myelopoiesis, which is linked to the increased incidence of myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibit immune regulatory function and sequester in bone...

journal_title：Immunity

authors： Pioli PD,Casero D,Montecino-Rodriguez E,Morrison SL,Dorshkind K

更新日期：2019-08-20 00:00:00

abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...

journal_title：Immunity

authors： Sugiyama T,Kohara H,Noda M,Nagasawa T

更新日期：2006-12-01 00:00:00

abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

journal_title：Immunity

authors： Postat J,Olekhnovitch R,Lemaître F,Bousso P

更新日期：2018-10-16 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...

journal_title：Immunity

authors： Munn DH,Sharma MD,Baban B,Harding HP,Zhang Y,Ron D,Mellor AL

更新日期：2005-05-01 00:00:00

abstract：:The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymp...

journal_title：Immunity

authors： Alhaj Hussen K,Vu Manh TP,Guimiot F,Nelson E,Chabaane E,Delord M,Barbier M,Berthault C,Dulphy N,Alberdi AJ,Burlen-Defranoux O,Socié G,Bories JC,Larghero J,Vanneaux V,Verhoeyen E,Wirth T,Dalod M,Gluckman JC,Cumano A

更新日期：2017-10-17 00:00:00

abstract：:In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

journal_title：Immunity

authors： Bowie AG

更新日期：2010-09-24 00:00:00

abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

journal_title：Immunity

authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

更新日期：2009-06-19 00:00:00

abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

journal_title：Immunity

authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

更新日期：2015-11-17 00:00:00

abstract：:Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...

journal_title：Immunity

authors： Tran S,Baba I,Poupel L,Dussaud S,Moreau M,Gélineau A,Marcelin G,Magréau-Davy E,Ouhachi M,Lesnik P,Boissonnas A,Le Goff W,Clausen BE,Yvan-Charvet L,Sennlaub F,Huby T,Gautier EL

更新日期：2020-09-15 00:00:00

abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...

journal_title：Immunity

authors： Simmons A,Gangadharan B,Hodges A,Sharrocks K,Prabhakar S,García A,Dwek R,Zitzmann N,McMichael A

更新日期：2005-12-01 00:00:00

abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...

journal_title：Immunity

authors： Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

更新日期：2007-04-01 00:00:00

abstract：:NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

journal_title：Immunity

authors： Mangan MS,Latz E

更新日期：2014-03-20 00:00:00

abstract：:While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...

journal_title：Immunity

authors： Ortiz M,Wine JW,Lohrey N,Ruscetti FW,Spence SE,Keller JR

更新日期：1999-02-01 00:00:00

abstract：:Activated T cells must mediate effector responses sufficiently to clear pathogens while avoiding excessive tissue damage. Here we have combined dynamic intravital microscopy with ex vivo assessments of T cell cytokine responses to generate a detailed spatiotemporal picture of CD4(+) T cell effector regulation in the s...

journal_title：Immunity

authors： Honda T,Egen JG,Lämmermann T,Kastenmüller W,Torabi-Parizi P,Germain RN

更新日期：2014-02-20 00:00:00

abstract：:The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...

journal_title：Immunity

authors： Delmas C,Dalmas E

更新日期：2018-03-20 00:00:00

abstract：:The role of the center of the immunological synapse (the central supramolecular activation cluster or cSMAC) is controversial. One model suggests that the role of the cSMAC depends on antigen quality and can both enhance signaling and receptor downregulation, whereas a second model proposes that the sole function of t...

journal_title：Immunity

authors： Cemerski S,Das J,Giurisato E,Markiewicz MA,Allen PM,Chakraborty AK,Shaw AS

更新日期：2008-09-19 00:00:00

abstract：:Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquir...

journal_title：Immunity

authors： Cheng LE,Hartmann K,Roers A,Krummel MF,Locksley RM

更新日期：2013-01-24 00:00:00

abstract：:The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and sh...

journal_title：Immunity

authors： Satoh-Takayama N,Kato T,Motomura Y,Kageyama T,Taguchi-Atarashi N,Kinoshita-Daitoku R,Kuroda E,Di Santo JP,Mimuro H,Moro K,Ohno H

更新日期：2020-04-14 00:00:00

abstract：:In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...

journal_title：Immunity

authors： Castillo PAC,Hand TW

更新日期：2018-05-15 00:00:00

abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...

journal_title：Immunity

authors： Stone EL,Pepper M,Katayama CD,Kerdiles YM,Lai CY,Emslie E,Lin YC,Yang E,Goldrath AW,Li MO,Cantrell DA,Hedrick SM

更新日期：2015-02-17 00:00:00

abstract：:Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mi...

journal_title：Immunity

authors： Voll RE,Jimi E,Phillips RJ,Barber DF,Rincon M,Hayday AC,Flavell RA,Ghosh S

更新日期：2000-11-01 00:00:00

abstract：:Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signali...

journal_title：Immunity

authors： Sprick MR,Weigand MA,Rieser E,Rauch CT,Juo P,Blenis J,Krammer PH,Walczak H

更新日期：2000-06-01 00:00:00

abstract：:TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antig...

journal_title：Immunity

authors： Mayerova D,Parke EA,Bursch LS,Odumade OA,Hogquist KA

更新日期：2004-09-01 00:00:00

abstract：:As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...

journal_title：Immunity

authors： Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M Jr,Loo YM,Oberst A

更新日期：2019-01-15 00:00:00

abstract：:Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select...

journal_title：Immunity

authors： Novakovic B,Wang C,Logie C

更新日期：2017-08-15 00:00:00

abstract：:Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killi...

journal_title：Immunity

authors： Mocikat R,Braumüller H,Gumy A,Egeter O,Ziegler H,Reusch U,Bubeck A,Louis J,Mailhammer R,Riethmüller G,Koszinowski U,Röcken M

更新日期：2003-10-01 00:00:00

abstract：:HLA-DM removes CLIP and other loosely bound peptides from MHC class II molecules. The crystal structures of class II molecules and of HLA-DM have not permitted identification of their interaction sites. Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly mutagenized DR3 alph...

journal_title：Immunity

authors： Doebele RC,Busch R,Scott HM,Pashine A,Mellins ED

更新日期：2000-10-01 00:00:00

abstract：:CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give pr...

journal_title：Immunity

authors： Im JS,Arora P,Bricard G,Molano A,Venkataswamy MM,Baine I,Jerud ES,Goldberg MF,Baena A,Yu KO,Ndonye RM,Howell AR,Yuan W,Cresswell P,Chang YT,Illarionov PA,Besra GS,Porcelli SA

更新日期：2009-06-19 00:00:00

abstract：:Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliv...

journal_title：Immunity

authors： Combadière B,Reis e Sousa C,Trageser C,Zheng LX,Kim CR,Lenardo MJ

更新日期：1998-09-01 00:00:00

abstract：:Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...

journal_title：Immunity

authors： Day PM,Esquivel F,Lukszo J,Bennink JR,Yewdell JW

更新日期：1995-02-01 00:00:00