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Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules.

Abstract：

:Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprisingly, RMA cells expressed 3- to 5-fold more cell surface peptide-receptive molecules. Metabolic radiolabeling of Kb-associated oligosaccharides with [1-3H]galactose demonstrated that despite a large difference in the fraction of Kb molecules in native conformation in detergent extracts, Kb transport rates from the trans-Golgi complex to the surfaces of RMA and RMA/S cells were similar. Thus, although considerable numbers of class I alpha chains reach the RMA/S cell surface, they are a less productive source of peptide-receptive molecules than class I molecules synthesized by TAP-expressing RMA cells, suggesting paradoxically that TAP functions to increase the amount of peptide-receptive molecules at the cell surface.

journal_name

Immunity

journal_title

Immunity

authors

Day PM,Esquivel F,Lukszo J,Bennink JR,Yewdell JW

doi

10.1016/s1074-7613(95)80014-x

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

137-47

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(95)80014-X

journal_volume

2

pub_type

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