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Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.

Abstract：

:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lymph node in naive mice, LACK-specific T cells expanded over 100-fold, and 70% acquired IL-4 expression by 96 hr. Despite their pathogenic role in susceptible mice, LACK-specific precursor frequency, expansion, and IL-4 expression were comparable between susceptible and resistant mice. When injected with unrelated antigen, Leishmania efficiently activated IL-4 expression from naive antigen-specific T cells. CD4 subset polarization in this highly characterized model occurs independently from IL-4 expression by naive T cells, which is activated indiscriminately after parasitism.

journal_name

Immunity

journal_title

Immunity

authors

Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

doi

10.1016/s1074-7613(02)00363-1

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

191-200

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00363-1

journal_volume

17

pub_type

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