Whole-body anatomy of human T cells.

abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...

journal_title：Immunity

authors： Thomas MD,Kremer CS,Ravichandran KS,Rajewsky K,Bender TP

更新日期：2005-09-01 00:00:00

abstract：:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...

journal_title：Immunity

authors： Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH

更新日期：2017-11-21 00:00:00

abstract：:The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...

journal_title：Immunity

authors： Ezekiel UR,Engler P,Stern D,Storb U

更新日期：1995-04-01 00:00:00

abstract：:Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic ...

journal_title：Immunity

authors： Chisolm DA,Cheng W,Colburn SA,Silva-Sanchez A,Meza-Perez S,Randall TD,Weinmann AS

更新日期：2019-07-16 00:00:00

abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

journal_title：Immunity

authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

更新日期：2018-06-19 00:00:00

abstract：:Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons...

journal_title：Immunity

authors： Andrews SF,Chambers MJ,Schramm CA,Plyler J,Raab JE,Kanekiyo M,Gillespie RA,Ransier A,Darko S,Hu J,Chen X,Yassine HM,Boyington JC,Crank MC,Chen GL,Coates E,Mascola JR,Douek DC,Graham BS,Ledgerwood JE,McDermott AB

更新日期：2019-08-20 00:00:00

abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

journal_title：Immunity

authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

更新日期：2020-06-16 00:00:00

abstract：:CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis. This asymmetry in outcome of infection between the two knockout strains is likely due ...

journal_title：Immunity

authors： Lazarevic V,Myers AJ,Scanga CA,Flynn JL

更新日期：2003-12-01 00:00:00

abstract：:The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...

journal_title：Immunity

authors： Dougan M,Dranoff G,Dougan SK

更新日期：2019-04-16 00:00:00

abstract：:The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in their HLA class I and KIR genes. More than 98% of the clones were inhibited by individual autologous class I allotypes, and every clone was inhibited by the combin...

journal_title：Immunity

authors： Valiante NM,Uhrberg M,Shilling HG,Lienert-Weidenbach K,Arnett KL,D'Andrea A,Phillips JH,Lanier LL,Parham P

更新日期：1997-12-01 00:00:00

abstract：:Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...

journal_title：Immunity

authors： Sutterwala FS,Ogura Y,Szczepanik M,Lara-Tejero M,Lichtenberger GS,Grant EP,Bertin J,Coyle AJ,Galán JE,Askenase PW,Flavell RA

更新日期：2006-03-01 00:00:00

abstract：:The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immunotherapy. In murine tumors, a large proportion of CD8+ TILs ha...

journal_title：Immunity

authors： Braun M,Aguilera AR,Sundarrajan A,Corvino D,Stannard K,Krumeich S,Das I,Lima LG,Meza Guzman LG,Li K,Li R,Salim N,Jorge MV,Ham S,Kelly G,Vari F,Lepletier A,Raghavendra A,Pearson S,Madore J,Jacquelin S,Effern M,

更新日期：2020-10-13 00:00:00

abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

journal_title：Immunity

authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

更新日期：2017-07-18 00:00:00

abstract：:Perforation of membranes and pore formation is mediated by polymerization of proteins of the immune system, complement C9 and Perforin, which share the conserved MACPF domain. In this issue of Immunity, Baran et al. (2009) identify the molecular mechanism initiating polymerization as charge interactions in the MACPF d...

journal_title：Immunity

authors： Podack ER

更新日期：2009-05-01 00:00:00

abstract：:In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...

journal_title：Immunity

authors： Castillo PAC,Hand TW

更新日期：2018-05-15 00:00:00

abstract：:The gut microbiota is a complex and plastic network of diverse organisms intricately connected with human physiology. Recent advances in profiling approaches of both the microbiota and the immune system now enable a deeper exploration of immunity-microbiota connections. An important next step is to elucidate a human-r...

journal_title：Immunity

authors： Spencer SP,Fragiadakis GK,Sonnenburg JL

更新日期：2019-08-20 00:00:00

abstract：:The thymus generates major histocompatibility complex (MHC)-restricted alphabetaT cells that only recognize antigenic ligands in association with MHC or MHC-like molecules. We hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that...

journal_title：Immunity

authors： Van Laethem F,Sarafova SD,Park JH,Tai X,Pobezinsky L,Guinter TI,Adoro S,Adams A,Sharrow SO,Feigenbaum L,Singer A

更新日期：2007-11-01 00:00:00

abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...

journal_title：Immunity

authors： Farlik M,Reutterer B,Schindler C,Greten F,Vogl C,Müller M,Decker T

更新日期：2010-07-23 00:00:00

abstract：:Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these Vgamma2Vdelta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induc...

journal_title：Immunity

authors： Das H,Groh V,Kuijl C,Sugita M,Morita CT,Spies T,Bukowski JF

更新日期：2001-07-01 00:00:00

abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

journal_title：Immunity

authors： McWhirter SM,Jefferies CA

更新日期：2020-07-14 00:00:00

abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

journal_title：Immunity

authors： Gangloff M,Gay NJ

更新日期：2008-03-01 00:00:00

abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

journal_title：Immunity

authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

更新日期：1996-09-01 00:00:00

abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

journal_title：Immunity

authors： Kioussis D

更新日期：2007-03-01 00:00:00

abstract：:The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....

journal_title：Immunity

authors： Chai Q,Onder L,Scandella E,Gil-Cruz C,Perez-Shibayama C,Cupovic J,Danuser R,Sparwasser T,Luther SA,Thiel V,Rülicke T,Stein JV,Hehlgans T,Ludewig B

更新日期：2013-05-23 00:00:00

abstract：:Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...

journal_title：Immunity

authors： Janetzki S,Britten CM,Kalos M,Levitsky HI,Maecker HT,Melief CJ,Old LJ,Romero P,Hoos A,Davis MM

更新日期：2009-10-16 00:00:00

abstract：:By virtue of its ability to couple the BCR to an inhibitory pathway, FcgammaRIIB can potentially determine the fate of B cells upon IgG immune complex engagement. We now provide evidence for FcgammaRIIB as a component of a peripheral tolerance pathway with the observation that RIIB-/- mice develop autoantibodies and a...

journal_title：Immunity

authors： Bolland S,Ravetch JV

更新日期：2000-08-01 00:00:00

abstract：:Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and it has been suggested that this might vary depending...

journal_title：Immunity

authors： Arora P,Baena A,Yu KO,Saini NK,Kharkwal SS,Goldberg MF,Kunnath-Velayudhan S,Carreño LJ,Venkataswamy MM,Kim J,Lazar-Molnar E,Lauvau G,Chang YT,Liu Z,Bittman R,Al-Shamkhani A,Cox LR,Jervis PJ,Veerapen N,Besra GS,Por

更新日期：2014-01-16 00:00:00

abstract：:The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-...

journal_title：Immunity

authors： Rao RR,Li Q,Odunsi K,Shrikant PA

更新日期：2010-01-29 00:00:00

abstract：:Upon TCR engagement, naive CD4 T cells differentiate toward the Th1 or Th2 phenotype. IL-4, acting through Stat6, plays a major role in Th2 differentiation; IL-2 has also been reported to be essential. Here, we report that retroviral (RV)-mediated expression of a constitutively active Stat5A mutant (STAT5A1*6) can ful...

journal_title：Immunity

authors： Zhu J,Cote-Sierra J,Guo L,Paul WE

更新日期：2003-11-01 00:00:00

abstract：:To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

journal_title：Immunity

authors： Semerad CL,Poursine-Laurent J,Liu F,Link DC

更新日期：1999-08-01 00:00:00