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GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

Abstract：

:The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Here, we review the functions of the β common cytokines in health and disease. We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of the basic biology of this cytokine family.

journal_name

Immunity

journal_title

Immunity

authors

Dougan M,Dranoff G,Dougan SK

doi

10.1016/j.immuni.2019.03.022

subject

Has Abstract

pub_date

2019-04-16 00:00:00

pages

796-811

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(19)30139-6

journal_volume

50

pub_type

杂志文章,评审

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