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Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.

Abstract：

:Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic variation in the widely used B6-CD45.2 and B6.SJL-CD45.1 congenic model, identifying substantial differences in SJL genetic content retained in B6.SJL-CD45.1 strains on the basis of the vendor source of the mice. Genes encoding PD-1, CD62L, Bcl-2, cathepsin E, and Cxcr4 were within SJL genetic content in at least one vendor source of B6.SJL-CD45.1 mice. SJL genetic content affected enhancer elements, gene regulation, protein expression, and amino acid content in CD4+ T helper 1 cells, and mice infected with influenza showed reduced expression of Cxcr4 on B6.SJL-CD45.1 T follicular helper cells. These findings provide information on experimental variables and aid in creating approaches that account for genetic variables.

journal_name

Immunity

journal_title

Immunity

authors

Chisolm DA,Cheng W,Colburn SA,Silva-Sanchez A,Meza-Perez S,Randall TD,Weinmann AS

doi

10.1016/j.immuni.2019.05.006

subject

Has Abstract

pub_date

2019-07-16 00:00:00

pages

155-168.e5

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(19)30226-2

journal_volume

51

pub_type

杂志文章

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