"MIATA"-minimal information about T cell assays.

abstract：:Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...

journal_title：Immunity

authors： Cros J,Cagnard N,Woollard K,Patey N,Zhang SY,Senechal B,Puel A,Biswas SK,Moshous D,Picard C,Jais JP,D'Cruz D,Casanova JL,Trouillet C,Geissmann F

更新日期：2010-09-24 00:00:00

abstract：:To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...

journal_title：Immunity

authors： Spiotto MT,Yu P,Rowley DA,Nishimura MI,Meredith SC,Gajewski TF,Fu YX,Schreiber H

更新日期：2002-12-01 00:00:00

abstract：:Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...

journal_title：Immunity

authors： Grawunder U,Leu TM,Schatz DG,Werner A,Rolink AG,Melchers F,Winkler TH

更新日期：1995-11-01 00:00:00

abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

journal_title：Immunity

authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

更新日期：2000-05-01 00:00:00

abstract：:Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-threonine kinase Ms...

journal_title：Immunity

authors： Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

更新日期：2018-11-20 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effecto...

journal_title：Immunity

authors： Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen P

更新日期：2008-03-01 00:00:00

abstract：:We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...

journal_title：Immunity

authors： Griffith TS,Yu X,Herndon JM,Green DR,Ferguson TA

更新日期：1996-07-01 00:00:00

abstract：:Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and it has been suggested that this might vary depending...

journal_title：Immunity

authors： Arora P,Baena A,Yu KO,Saini NK,Kharkwal SS,Goldberg MF,Kunnath-Velayudhan S,Carreño LJ,Venkataswamy MM,Kim J,Lazar-Molnar E,Lauvau G,Chang YT,Liu Z,Bittman R,Al-Shamkhani A,Cox LR,Jervis PJ,Veerapen N,Besra GS,Por

更新日期：2014-01-16 00:00:00

abstract：:Cell death in B cell terminal differentiation rapidly follows cell cycle arrest in IL-6 differentiation of EBV-immortalized, IgG-bearing human lymphoblastoid cells in vitro. G1 arrest is now found to coincide with repression of EBNA2 and LMP1, two EBV genes essential for B cell transformation, without activation of th...

journal_title：Immunity

authors： Altmeyer A,Simmons RC,Krajewski S,Reed JC,Bornkamm GW,Chen-Kiang S

更新日期：1997-11-01 00:00:00

abstract：:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...

journal_title：Immunity

authors： Sutkowski N,Conrad B,Thorley-Lawson DA,Huber BT

更新日期：2001-10-01 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reacti...

journal_title：Immunity

authors： Triller G,Scally SW,Costa G,Pissarev M,Kreschel C,Bosch A,Marois E,Sack BK,Murugan R,Salman AM,Janse CJ,Khan SM,Kappe SHI,Adegnika AA,Mordmüller B,Levashina EA,Julien JP,Wardemann H

更新日期：2017-12-19 00:00:00

abstract：:HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and active antiviral cellular immune responses. In contrast, sooty mangabey monkeys that represent natural hosts for SIV infection do not develop AIDS despite high l...

journal_title：Immunity

authors： Silvestri G,Sodora DL,Koup RA,Paiardini M,O'Neil SP,McClure HM,Staprans SI,Feinberg MB

更新日期：2003-03-01 00:00:00

abstract：:Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...

journal_title：Immunity

authors： Colgan J,Asmal M,Neagu M,Yu B,Schneidkraut J,Lee Y,Sokolskaja E,Andreotti A,Luban J

更新日期：2004-08-01 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell development and NF-kappaB activation, conditionally TRAF2-deficient mice were produced. B cells lacking TRAF2 expression in these mice possessed a selective survival advantage, accumulated in the lymph nodes and splenic marginal zone...

journal_title：Immunity

authors： Grech AP,Amesbury M,Chan T,Gardam S,Basten A,Brink R

更新日期：2004-11-01 00:00:00

abstract：:Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...

journal_title：Immunity

authors： Hamilton SE,Jameson SC

更新日期：2007-08-01 00:00:00

abstract：:Transcriptional regulation during CD4+ T cell fate decisions enables their differentiation into distinct states, guiding immune responses toward antibody production via Tfh cells or inflammation by Teff cells. Tfh-Teff cell fate commitment is regulated by mutual antagonism between the transcription factors Bcl6 and Bl...

journal_title：Immunity

authors： Krishnamoorthy V,Kannanganat S,Maienschein-Cline M,Cook SL,Chen J,Bahroos N,Sievert E,Corse E,Chong A,Sciammas R

更新日期：2017-09-19 00:00:00

abstract：:The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research. ...

journal_title：Immunity

authors： Neurath MF,Chiriac MT

更新日期：2019-11-19 00:00:00

abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...

journal_title：Immunity

authors： Nguyen HN,Noss EH,Mizoguchi F,Huppertz C,Wei KS,Watts GFM,Brenner MB

更新日期：2017-02-21 00:00:00

abstract：:Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat(Y136F) mice) accumulate CD4(+) T cells that trigger autoimmunity and inflammation. Here we show that equipping postthymic CD4(+) T cells with LAT...

journal_title：Immunity

authors： Mingueneau M,Roncagalli R,Grégoire C,Kissenpfennig A,Miazek A,Archambaud C,Wang Y,Perrin P,Bertosio E,Sansoni A,Richelme S,Locksley RM,Aguado E,Malissen M,Malissen B

更新日期：2009-08-21 00:00:00

abstract：:To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

journal_title：Immunity

authors： Semerad CL,Poursine-Laurent J,Liu F,Link DC

更新日期：1999-08-01 00:00:00

abstract：:Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of T...

journal_title：Immunity

authors： Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT

更新日期：2010-05-28 00:00:00

abstract：:The mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFkappaB and IRFs and the induction of interferons in response to viral infection. In vitro studies have also suggested that MAVS is required for interferon induction by cytosolic DNA, but the in vivo evidence is lacking. By generating MAV...

journal_title：Immunity

authors： Sun Q,Sun L,Liu HH,Chen X,Seth RB,Forman J,Chen ZJ

更新日期：2006-05-01 00:00:00

abstract：:The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant ...

journal_title：Immunity

authors： Van Molle W,Wielockx B,Mahieu T,Takada M,Taniguchi T,Sekikawa K,Libert C

更新日期：2002-05-01 00:00:00

abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...

journal_title：Immunity

authors： Gulbins E,Bissonnette R,Mahboubi A,Martin S,Nishioka W,Brunner T,Baier G,Baier-Bitterlich G,Byrd C,Lang F

更新日期：1995-04-01 00:00:00

abstract：:Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

journal_title：Immunity

authors： Neuenhahn M,Busch DH

更新日期：2013-01-24 00:00:00

abstract：:Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset ...

journal_title：Immunity

authors： Seydoux E,Homad LJ,MacCamy AJ,Parks KR,Hurlburt NK,Jennewein MF,Akins NR,Stuart AB,Wan YH,Feng J,Whaley RE,Singh S,Boeckh M,Cohen KW,McElrath MJ,Englund JA,Chu HY,Pancera M,McGuire AT,Stamatatos L

更新日期：2020-07-14 00:00:00