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Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

Abstract：

:HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and active antiviral cellular immune responses. In contrast, sooty mangabey monkeys that represent natural hosts for SIV infection do not develop AIDS despite high levels of virus replication and limited antiviral CD8(+) T cell responses. We report here that SIV-infected mangabeys maintain preserved T lymphocyte populations and regenerative capacity and manifest far lower levels of aberrant immune activation and apoptosis than are seen in pathogenic SIV and HIV infections. These data suggest that direct consequences of virus replication alone cannot account for progressive CD4(+) T cell depletion leading to AIDS. Rather, attenuated immune activation enables SIV-infected mangabeys to avoid the bystander damage seen in pathogenic infections and protects them from developing AIDS.

journal_name

Immunity

journal_title

Immunity

authors

Silvestri G,Sodora DL,Koup RA,Paiardini M,O'Neil SP,McClure HM,Staprans SI,Feinberg MB

doi

10.1016/s1074-7613(03)00060-8

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

441-52

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(03)00060-8

journal_volume

18

pub_type

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