Abstract：
:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effector function and TCR-CD8 colocalization were restored with galectin disaccharide ligands, suggesting that the binding of TCR to galectin plays a role in the distancing of TCR from CD8. These findings appear to be applicable in vivo, as TCR was observed to be distant from CD8 on human tumor-infiltrating lymphocytes, which were anergic. These lymphocytes recovered effector functions and TCR-CD8 colocalization after ex vivo treatment with galectin disaccharide ligands. The separation of TCR and CD8 molecules could be one major mechanism of anergy in tumors and other chronic stimulation conditions.
journal_name
Immunityjournal_title
Immunityauthors
Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen Pdoi
10.1016/j.immuni.2008.01.011subject
Has Abstractpub_date
2008-03-01 00:00:00pages
414-24issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(08)00070-8journal_volume
28pub_type
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