Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.

abstract：:We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on sever...

journal_title：Immunity

authors： Khan G,Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

更新日期：1996-08-01 00:00:00

abstract：:Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...

journal_title：Immunity

authors： Yatim N,Albert ML

更新日期：2011-10-28 00:00:00

abstract：:Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...

journal_title：Immunity

authors： Sutterwala FS,Ogura Y,Szczepanik M,Lara-Tejero M,Lichtenberger GS,Grant EP,Bertin J,Coyle AJ,Galán JE,Askenase PW,Flavell RA

更新日期：2006-03-01 00:00:00

abstract：:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

journal_title：Immunity

authors： Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

更新日期：2013-09-19 00:00:00

abstract：:Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined. Here, w...

journal_title：Immunity

authors： Kawalekar OU,O'Connor RS,Fraietta JA,Guo L,McGettigan SE,Posey AD Jr,Patel PR,Guedan S,Scholler J,Keith B,Snyder NW,Blair IA,Milone MC,June CH

更新日期：2016-02-16 00:00:00

abstract：:Cell death in B cell terminal differentiation rapidly follows cell cycle arrest in IL-6 differentiation of EBV-immortalized, IgG-bearing human lymphoblastoid cells in vitro. G1 arrest is now found to coincide with repression of EBNA2 and LMP1, two EBV genes essential for B cell transformation, without activation of th...

journal_title：Immunity

authors： Altmeyer A,Simmons RC,Krajewski S,Reed JC,Bornkamm GW,Chen-Kiang S

更新日期：1997-11-01 00:00:00

abstract：:By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL failed to lyse autologous EBV-transformed B cells, even though the latter express the protein. This is due to the presence in these cells of immunoproteasomes, w...

journal_title：Immunity

authors： Morel S,Lévy F,Burlet-Schiltz O,Brasseur F,Probst-Kepper M,Peitrequin AL,Monsarrat B,Van Velthoven R,Cerottini JC,Boon T,Gairin JE,Van den Eynde BJ

更新日期：2000-01-01 00:00:00

abstract：:Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...

journal_title：Immunity

authors： Niiro H,Clark EA

更新日期：2003-11-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

journal_title：Immunity

authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

更新日期：2020-11-17 00:00:00

abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

journal_title：Immunity

authors： Hogquist KA

更新日期：2006-07-01 00:00:00

abstract：:In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing. ...

journal_title：Immunity

authors： Yang TB,Kim BS

更新日期：2020-08-18 00:00:00

abstract：:Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...

journal_title：Immunity

authors： Gunzer M,Schäfer A,Borgmann S,Grabbe S,Zänker KS,Bröcker EB,Kämpgen E,Friedl P

更新日期：2000-09-01 00:00:00

abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

journal_title：Immunity

authors： Stone SL,Lund FE

更新日期：2016-08-16 00:00:00

abstract：:Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. ...

journal_title：Immunity

authors： Murphy AG,Maloy KJ

更新日期：2018-06-19 00:00:00

abstract：:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the i...

journal_title：Immunity

authors： Coffman RL,Sher A,Seder RA

更新日期：2010-10-29 00:00:00

abstract：:The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...

journal_title：Immunity

authors： Boudreau JE,Liu XR,Zhao Z,Zhang A,Shultz LD,Greiner DL,Dupont B,Hsu KC

更新日期：2016-08-16 00:00:00

abstract：:The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

journal_title：Immunity

authors： Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

更新日期：2013-11-14 00:00:00

abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

journal_title：Immunity

authors： Cancro MP

更新日期：2004-06-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...

journal_title：Immunity

authors： Munn DH,Sharma MD,Baban B,Harding HP,Zhang Y,Ron D,Mellor AL

更新日期：2005-05-01 00:00:00

abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

journal_title：Immunity

authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

更新日期：1998-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how thi...

journal_title：Immunity

authors： Kirk P,Bazan JF

更新日期：2005-10-01 00:00:00

abstract：:Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...

journal_title：Immunity

authors： Wang Y,Ning X,Gao P,Wu S,Sha M,Lv M,Zhou X,Gao J,Fang R,Meng G,Su X,Jiang Z

更新日期：2017-03-21 00:00:00

abstract：:MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cel...

journal_title：Immunity

authors： Belver L,de Yébenes VG,Ramiro AR

更新日期：2010-11-24 00:00:00

abstract：:The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, and a lack of new mouse mutants. By using N-ethyl-N-nitrosourea (ENU) mutagene...

journal_title：Immunity

authors： Yu P,Constien R,Dear N,Katan M,Hanke P,Bunney TD,Kunder S,Quintanilla-Martinez L,Huffstadt U,Schröder A,Jones NP,Peters T,Fuchs H,de Angelis MH,Nehls M,Grosse J,Wabnitz P,Meyer TP,Yasuda K,Schiemann M,Schneider-Fr

更新日期：2005-04-01 00:00:00

abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

journal_title：Immunity

authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

更新日期：2020-02-18 00:00:00

abstract：:Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...

journal_title：Immunity

authors： Geissmann F,Jung S,Littman DR

更新日期：2003-07-01 00:00:00

abstract：:Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyroph...

journal_title：Immunity

authors： Morita CT,Beckman EM,Bukowski JF,Tanaka Y,Band H,Bloom BR,Golan DE,Brenner MB

更新日期：1995-10-01 00:00:00

abstract：:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

journal_title：Immunity

authors： Soares MP

更新日期：2014-08-21 00:00:00

abstract：:In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithe...

journal_title：Immunity

authors： Goldrath AW,Hedrick SM

更新日期：2005-08-01 00:00:00

abstract：:IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we d...

journal_title：Immunity

authors： Yang Z,Sullivan BM,Allen CD

更新日期：2012-05-25 00:00:00