"Nuts and bolts" of disease tolerance.

Abstract:

:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice.

journal_name

Immunity

journal_title

Immunity

authors

Soares MP

doi

10.1016/j.immuni.2014.07.011

subject

Has Abstract

pub_date

2014-08-21 00:00:00

pages

176-8

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(14)00269-6

journal_volume

41

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Plague's partners in crime.

    abstract::The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopat...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.09.003

    authors: Davis KM,Isberg RR

    更新日期:2014-09-18 00:00:00

  • What doesn't kill you makes you stronger: the anti-inflammatory effect of neutrophil respiratory burst.

    abstract::In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2013.12.003

    authors: Borregaard N

    更新日期:2014-01-16 00:00:00

  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

    abstract::Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80284-8

    authors: Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

    更新日期:1997-04-01 00:00:00

  • MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.

    abstract::Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.06.016

    authors: Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN

    更新日期:2014-08-21 00:00:00

  • Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.

    abstract::A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) maintain GCs through the uptake and cycling of complement-opsonized immun...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.12.014

    authors: Das A,Heesters BA,Bialas A,O'Flynn J,Rifkin IR,Ochando J,Mittereder N,Carlesso G,Herbst R,Carroll MC

    更新日期:2017-01-17 00:00:00

  • Plasmacytoid Dendritic Cells: Development, Regulation, and Function.

    abstract::Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2018.12.027

    authors: Reizis B

    更新日期:2019-01-15 00:00:00

  • Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

    abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(94)90010-8

    authors: Chen J,Stewart V,Spyrou G,Hilberg F,Wagner EF,Alt FW

    更新日期:1994-04-01 00:00:00

  • An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene.

    abstract::Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80263-0

    authors: Rinkenberger JL,Wallin JJ,Johnson KW,Koshland ME

    更新日期:1996-10-01 00:00:00

  • Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.

    abstract::Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal anti...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.10.005

    authors: Guthmiller JJ,Lan LY,Fernández-Quintero ML,Han J,Utset HA,Bitar DJ,Hamel NJ,Stovicek O,Li L,Tepora M,Henry C,Neu KE,Dugan HL,Borowska MT,Chen YQ,Liu STH,Stamper CT,Zheng NY,Huang M,Palm AE,García-Sastre A,Nachba

    更新日期:2020-12-15 00:00:00

  • Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.

    abstract::In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2008.12.007

    authors: Kortum RL,Samelson LE

    更新日期:2009-01-16 00:00:00

  • IL-2: Change Structure … Change Function.

    abstract::In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2015.05.002

    authors: Bluestone JA,Crellin N,Trotta E

    更新日期:2015-05-19 00:00:00

  • A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.

    abstract::Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.04.024

    authors: Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

    更新日期:2008-07-18 00:00:00

  • Late arrival: recruiting coreceptors to the T cell receptor complex.

    abstract::In this issue of Immunity, Jiang et al. (2011) provide evidence that the CD8 coreceptor is recruited to the T cell receptor (TCR) complex after initial TCR triggering where it stabilizes the TCR-peptide-major histocompatibility complex interaction. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2011.01.001

    authors: van der Merwe PA,Cordoba SP

    更新日期:2011-01-28 00:00:00

  • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.

    abstract::T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80480-x

    authors: Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS

    更新日期:1996-06-01 00:00:00

  • Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.

    abstract::Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lym...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.06.027

    authors: Takeda A,Hollmén M,Dermadi D,Pan J,Brulois KF,Kaukonen R,Lönnberg T,Boström P,Koskivuo I,Irjala H,Miyasaka M,Salmi M,Butcher EC,Jalkanen S

    更新日期:2019-09-17 00:00:00

  • Central tolerance matters.

    abstract::In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithe...

    journal_title:Immunity

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.immuni.2005.08.004

    authors: Goldrath AW,Hedrick SM

    更新日期:2005-08-01 00:00:00

  • Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases.

    abstract::Inflammation mediated by antibody-antigen complexes contributes to autoimmune diseases. Mice deficient in the common Fcgamma-chain are protected from IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and FcR-bearing macrophages, and mast cells have been assigned primary roles in these proce...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.04.013

    authors: Tsuboi N,Asano K,Lauterbach M,Mayadas TN

    更新日期:2008-06-01 00:00:00

  • Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

    abstract::Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(01)00246-1

    authors: Mueller YM,De Rosa SC,Hutton JA,Witek J,Roederer M,Altman JD,Katsikis PD

    更新日期:2001-12-01 00:00:00

  • Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

    abstract::The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, and a lack of new mouse mutants. By using N-ethyl-N-nitrosourea (ENU) mutagene...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2005.01.018

    authors: Yu P,Constien R,Dear N,Katan M,Hanke P,Bunney TD,Kunder S,Quintanilla-Martinez L,Huffstadt U,Schröder A,Jones NP,Peters T,Fuchs H,de Angelis MH,Nehls M,Grosse J,Wabnitz P,Meyer TP,Yasuda K,Schiemann M,Schneider-Fr

    更新日期:2005-04-01 00:00:00

  • Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome.

    abstract::Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.09.008

    authors: Guo C,Xie S,Chi Z,Zhang J,Liu Y,Zhang L,Zheng M,Zhang X,Xia D,Ke Y,Lu L,Wang D

    更新日期:2016-10-18 00:00:00

  • Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing.

    abstract::We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90064-0

    authors: Chen C,Nagy Z,Prak EL,Weigert M

    更新日期:1995-12-01 00:00:00

  • How do adjuvants work? Important considerations for new generation adjuvants.

    abstract::In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2007.11.003

    authors: McKee AS,Munks MW,Marrack P

    更新日期:2007-11-01 00:00:00

  • WECHE: a novel hematopoietic regulatory factor.

    abstract::Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80167-3

    authors: Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

    更新日期:2000-02-01 00:00:00

  • Viral Anti-CRISPR Tactics: No Success without Sacrifice.

    abstract::Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2018.08.023

    authors: van Gent M,Gack MU

    更新日期:2018-09-18 00:00:00

  • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

    abstract::An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed I...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00324-2

    authors: Pflanz S,Timans JC,Cheung J,Rosales R,Kanzler H,Gilbert J,Hibbert L,Churakova T,Travis M,Vaisberg E,Blumenschein WM,Mattson JD,Wagner JL,To W,Zurawski S,McClanahan TK,Gorman DM,Bazan JF,de Waal Malefyt R,Rennick D,

    更新日期:2002-06-01 00:00:00

  • Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way.

    abstract::Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2015.12.019

    authors: Schultze JL,Beyer M

    更新日期:2016-01-19 00:00:00

  • T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.

    abstract::Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4+ T cells needed for germinal center...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.04.011

    authors: Crotty S

    更新日期:2019-05-21 00:00:00

  • Loss of CD47 Makes Dendritic Cells See Red.

    abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2015.09.008

    authors: van den Berg TK,van Bruggen R

    更新日期:2015-10-20 00:00:00

  • Aiolos regulates B cell activation and maturation to effector state.

    abstract::Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80637-8

    authors: Wang JH,Avitahl N,Cariappa A,Friedrich C,Ikeda T,Renold A,Andrikopoulos K,Liang L,Pillai S,Morgan BA,Georgopoulos K

    更新日期:1998-10-01 00:00:00

  • IFN-γ signals a changing of the guards.

    abstract::After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.06.007

    authors: Yap GS,Rivera A

    更新日期:2012-06-29 00:00:00