Abstract:
:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice.
journal_name
Immunityjournal_title
Immunityauthors
Soares MPdoi
10.1016/j.immuni.2014.07.011subject
Has Abstractpub_date
2014-08-21 00:00:00pages
176-8issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(14)00269-6journal_volume
41pub_type
评论,杂志文章相关文献
IMMUNITY文献大全abstract::The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopat...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.09.003
更新日期:2014-09-18 00:00:00
abstract::In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2013.12.003
更新日期:2014-01-16 00:00:00
abstract::Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80284-8
更新日期:1997-04-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.06.016
更新日期:2014-08-21 00:00:00
abstract::A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) maintain GCs through the uptake and cycling of complement-opsonized immun...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.12.014
更新日期:2017-01-17 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2018.12.027
更新日期:2019-01-15 00:00:00
abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90010-8
更新日期:1994-04-01 00:00:00
abstract::Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80263-0
更新日期:1996-10-01 00:00:00
abstract::Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal anti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.10.005
更新日期:2020-12-15 00:00:00
abstract::In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2008.12.007
更新日期:2009-01-16 00:00:00
abstract::In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.05.002
更新日期:2015-05-19 00:00:00
abstract::Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.024
更新日期:2008-07-18 00:00:00
abstract::In this issue of Immunity, Jiang et al. (2011) provide evidence that the CD8 coreceptor is recruited to the T cell receptor (TCR) complex after initial TCR triggering where it stabilizes the TCR-peptide-major histocompatibility complex interaction. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.01.001
更新日期:2011-01-28 00:00:00
abstract::T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80480-x
更新日期:1996-06-01 00:00:00
abstract::Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lym...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.06.027
更新日期:2019-09-17 00:00:00
abstract::In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithe...
journal_title:Immunity
pub_type: 评论,杂志文章,评审
doi:10.1016/j.immuni.2005.08.004
更新日期:2005-08-01 00:00:00
abstract::Inflammation mediated by antibody-antigen complexes contributes to autoimmune diseases. Mice deficient in the common Fcgamma-chain are protected from IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and FcR-bearing macrophages, and mast cells have been assigned primary roles in these proce...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.013
更新日期:2008-06-01 00:00:00
abstract::Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00246-1
更新日期:2001-12-01 00:00:00
abstract::The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, and a lack of new mouse mutants. By using N-ethyl-N-nitrosourea (ENU) mutagene...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.01.018
更新日期:2005-04-01 00:00:00
abstract::Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.008
更新日期:2016-10-18 00:00:00
abstract::We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90064-0
更新日期:1995-12-01 00:00:00
abstract::In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2007.11.003
更新日期:2007-11-01 00:00:00
abstract::Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80167-3
更新日期:2000-02-01 00:00:00
abstract::Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.023
更新日期:2018-09-18 00:00:00
abstract::An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed I...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00324-2
更新日期:2002-06-01 00:00:00
abstract::Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.12.019
更新日期:2016-01-19 00:00:00
abstract::Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4+ T cells needed for germinal center...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.04.011
更新日期:2019-05-21 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80637-8
更新日期:1998-10-01 00:00:00
abstract::After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2012.06.007
更新日期:2012-06-29 00:00:00