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Unique maturation program of the IgE response in vivo.

Abstract：

:A key event in the pathogenesis of asthma and allergies is the production of IgE antibodies. We show here that IgE(+) cells were exceptional because they were largely found outside germinal centers and expressed, from very early on, a genetic program of plasma cells. In spite of their extragerminal center localization, IgE(+) cells showed signs of somatic hypermutation and affinity maturation. We demonstrated that high-affinity IgE(+) cells could be generated through a unique differentiation program that involved two phases: a pre-IgE phase in which somatic hypermutation and affinity maturation take place in IgG1(+) cells, and a post-IgE-switching phase in which IgE cells differentiate swiftly into plasma cells. Our results have implications for the understanding of IgE memory responses in allergy.

journal_name

Immunity

journal_title

Immunity

authors

Erazo A,Kutchukhidze N,Leung M,Christ AP,Urban JF Jr,Curotto de Lafaille MA,Lafaille JJ

doi

10.1016/j.immuni.2006.12.006

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

191-203

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(07)00133-1

journal_volume

26

pub_type

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