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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.

Abstract：

:Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection.

journal_name

Immunity

journal_title

Immunity

authors

Kim MV,Ouyang W,Liao W,Zhang MQ,Li MO

doi

10.1016/j.immuni.2013.07.013

subject

Has Abstract

pub_date

2013-08-22 00:00:00

pages

286-97

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(13)00321-X

journal_volume

39

pub_type

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