Abstract:
:Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is required for formation of the immune synapse and T cell activation. Here, we showed that oxidatively stressed human T cells were impaired in chemotaxis- and costimulation-induced F-actin modulation. Although cofilin was dephosphorylated, steady-state F-actin levels increased under oxidative stress conditions. Mass spectrometry revealed that cofilin itself was a target for oxidation. Cofilin oxidation induced formation of an intramolecular disulfide bridge and loss of its Ser3 phosphorylation. Importantly, dephosphorylated oxidized cofilin, although still able to bind to F-actin, did not mediate F-actin depolymerization. Impairing actin dynamics through oxidation of cofilin provides a molecular explanation for the T cell hyporesponsiveness caused by oxidative stress.
journal_name
Immunityjournal_title
Immunityauthors
Klemke M,Wabnitz GH,Funke F,Funk B,Kirchgessner H,Samstag Ydoi
10.1016/j.immuni.2008.06.016subject
Has Abstractpub_date
2008-09-19 00:00:00pages
404-13issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(08)00369-5journal_volume
29pub_type
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