In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos.

abstract：:As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...

journal_title：Immunity

authors： Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M Jr,Loo YM,Oberst A

更新日期：2019-01-15 00:00:00

abstract：:Perforin-mediated cytotoxicity is essential for clearance of primary LCMV infection. BALB/c-perforin-deficient (PKO) mice survived LCMV infection by deleting NP(118)-specific CD8(+) T cells whereas vaccination of PKO mice with Listeria expressing NP(118) generated a stable memory CD8(+) T cell population. However, >85...

journal_title：Immunity

authors： Badovinac VP,Hamilton SE,Harty JT

更新日期：2003-04-01 00:00:00

abstract：:Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes...

journal_title：Immunity

authors： Koltsova EK,Grivennikov SI

更新日期：2014-05-15 00:00:00

abstract：:Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognitio...

journal_title：Immunity

authors： Scotet E,Martinez LO,Grant E,Barbaras R,Jenö P,Guiraud M,Monsarrat B,Saulquin X,Maillet S,Estève JP,Lopez F,Perret B,Collet X,Bonneville M,Champagne E

更新日期：2005-01-01 00:00:00

abstract：:Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under...

journal_title：Immunity

authors： Coxon A,Cullere X,Knight S,Sethi S,Wakelin MW,Stavrakis G,Luscinskas FW,Mayadas TN

更新日期：2001-06-01 00:00:00

abstract：:Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function. CXCL16 was constitutiv...

journal_title：Immunity

authors： Satoh-Takayama N,Serafini N,Verrier T,Rekiki A,Renauld JC,Frankel G,Di Santo JP

更新日期：2014-11-20 00:00:00

abstract：:Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

journal_title：Immunity

authors： Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

更新日期：2000-07-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and re...

journal_title：Immunity

authors： Horton B,Spranger S

更新日期：2018-07-17 00:00:00

abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

journal_title：Immunity

authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

更新日期：2020-02-18 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

journal_title：Immunity

authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

更新日期：2013-09-19 00:00:00

abstract：:The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

journal_title：Immunity

authors： Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

更新日期：2011-06-24 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Co...

journal_title：Immunity

authors： Kim MV,Ouyang W,Liao W,Zhang MQ,Li MO

更新日期：2013-08-22 00:00:00

abstract：:We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...

journal_title：Immunity

authors： Thorsson V,Gibbs DL,Brown SD,Wolf D,Bortone DS,Ou Yang TH,Porta-Pardo E,Gao GF,Plaisier CL,Eddy JA,Ziv E,Culhane AC,Paull EO,Sivakumar IKA,Gentles AJ,Malhotra R,Farshidfar F,Colaprico A,Parker JS,Mose LE,Vo NS,L

更新日期：2018-04-17 00:00:00

abstract：:Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...

journal_title：Immunity

authors： Guo C,Xie S,Chi Z,Zhang J,Liu Y,Zhang L,Zheng M,Zhang X,Xia D,Ke Y,Lu L,Wang D

更新日期：2016-10-18 00:00:00

abstract：:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the i...

journal_title：Immunity

authors： Coffman RL,Sher A,Seder RA

更新日期：2010-10-29 00:00:00

abstract：:Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...

journal_title：Immunity

authors： Liu X,Nemeth DP,McKim DB,Zhu L,DiSabato DJ,Berdysz O,Gorantla G,Oliver B,Witcher KG,Wang Y,Negray CE,Vegesna RS,Sheridan JF,Godbout JP,Robson MJ,Blakely RD,Popovich PG,Bilbo SD,Quan N

更新日期：2019-02-19 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage development, maintenance, and function. The development of both Langerhans cells (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1. Here we show that in both mice and humans, interleukin-34 (...

journal_title：Immunity

authors： Greter M,Lelios I,Pelczar P,Hoeffel G,Price J,Leboeuf M,Kündig TM,Frei K,Ginhoux F,Merad M,Becher B

更新日期：2012-12-14 00:00:00

abstract：:The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...

journal_title：Immunity

authors： Hou Y,Liang H,Rao E,Zheng W,Huang X,Deng L,Zhang Y,Yu X,Xu M,Mauceri H,Arina A,Weichselbaum RR,Fu YX

更新日期：2018-09-18 00:00:00

abstract：:Anopheles gambiae uses effective immune responses, including phagocytosis, to fight microbial infection. We have developed a semiquantitative phagocytosis test and used it in conjunction with dsRNA gene silencing to test the in vivo roles of 71 candidate genes in phagocytosis of Escherichia coli and Staphylococcus aur...

journal_title：Immunity

authors： Moita LF,Wang-Sattler R,Michel K,Zimmermann T,Blandin S,Levashina EA,Kafatos FC

更新日期：2005-07-01 00:00:00

abstract：:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...

journal_title：Immunity

authors： Zhang X,Sun S,Hwang I,Tough DF,Sprent J

更新日期：1998-05-01 00:00:00

abstract：:De Libero et al. (2005) demonstrate in this issue of Immunity that bacterial infection leads to increased synthesis of autologous glycolipids that are recognized by CD1-restricted human T cells, indicating that recognition of inducible self-glycolipids could be a mechanism for microbial detection. This mechanism also ...

journal_title：Immunity

authors： Kronenberg M,Kinjo Y

更新日期：2005-06-01 00:00:00

abstract：:To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell development and NF-kappaB activation, conditionally TRAF2-deficient mice were produced. B cells lacking TRAF2 expression in these mice possessed a selective survival advantage, accumulated in the lymph nodes and splenic marginal zone...

journal_title：Immunity

authors： Grech AP,Amesbury M,Chan T,Gardam S,Basten A,Brink R

更新日期：2004-11-01 00:00:00

abstract：:Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis. ...

journal_title：Immunity

authors： Kolb JP,Martinez J

更新日期：2016-02-16 00:00:00

abstract：:Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of aff...

journal_title：Immunity

authors： Mesin L,Ersching J,Victora GD

更新日期：2016-09-20 00:00:00

abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

journal_title：Immunity

authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

更新日期：1996-11-01 00:00:00

abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

journal_title：Immunity

authors： Pascual-Gil S,Epelman S

更新日期：2018-11-20 00:00:00

abstract：:Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune ...

journal_title：Immunity

authors： Galon J,Angell HK,Bedognetti D,Marincola FM

更新日期：2013-07-25 00:00:00

abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

journal_title：Immunity

authors： McWhirter SM,Jefferies CA

更新日期：2020-07-14 00:00:00