In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae.

abstract：:Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...

journal_title：Immunity

authors： Sutterwala FS,Ogura Y,Szczepanik M,Lara-Tejero M,Lichtenberger GS,Grant EP,Bertin J,Coyle AJ,Galán JE,Askenase PW,Flavell RA

更新日期：2006-03-01 00:00:00

abstract：:Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf...

journal_title：Immunity

authors： Garg S,Sharma M,Ung C,Tuli A,Barral DC,Hava DL,Veerapen N,Besra GS,Hacohen N,Brenner MB

更新日期：2011-08-26 00:00:00

abstract：:T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/d...

journal_title：Immunity

authors： Speir JA,Abdel-Motal UM,Jondal M,Wilson IA

更新日期：1999-01-01 00:00:00

abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

journal_title：Immunity

authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

更新日期：1996-11-01 00:00:00

abstract：:Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory T (Treg) cells. Because of its importance for Treg cells, we exam...

journal_title：Immunity

authors： Laurence A,Tato CM,Davidson TS,Kanno Y,Chen Z,Yao Z,Blank RB,Meylan F,Siegel R,Hennighausen L,Shevach EM,O'shea JJ

更新日期：2007-03-01 00:00:00

abstract：:Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...

journal_title：Immunity

authors： Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

更新日期：1997-04-01 00:00:00

abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

journal_title：Immunity

authors： McWhirter SM,Jefferies CA

更新日期：2020-07-14 00:00:00

abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

journal_title：Immunity

authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

更新日期：2017-07-18 00:00:00

abstract：:The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...

journal_title：Immunity

authors： Alvarez-Diaz S,Dillon CP,Lalaoui N,Tanzer MC,Rodriguez DA,Lin A,Lebois M,Hakem R,Josefsson EC,O'Reilly LA,Silke J,Alexander WS,Green DR,Strasser A

更新日期：2016-09-20 00:00:00

abstract：:As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...

journal_title：Immunity

authors： Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M Jr,Loo YM,Oberst A

更新日期：2019-01-15 00:00:00

abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...

journal_title：Immunity

authors： Conejo-Garcia JR,Rutkowski MR

更新日期：2015-12-15 00:00:00

abstract：:The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple extracellular signals to transcriptional responses. The capacity of mIg to activate these MAP kinases is synergisticall...

journal_title：Immunity

authors： Tooze RM,Doody GM,Fearon DT

更新日期：1997-07-01 00:00:00

abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

journal_title：Immunity

authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

更新日期：1998-06-01 00:00:00

abstract：:Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...

journal_title：Immunity

authors： Wang JH,Avitahl N,Cariappa A,Friedrich C,Ikeda T,Renold A,Andrikopoulos K,Liang L,Pillai S,Morgan BA,Georgopoulos K

更新日期：1998-10-01 00:00:00

abstract：:T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation. ...

journal_title：Immunity

authors： Sundrud MS,Rao A

更新日期：2008-01-01 00:00:00

abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

journal_title：Immunity

authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

更新日期：2016-06-21 00:00:00

abstract：:Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...

journal_title：Immunity

authors： Escobar TM,Kanellopoulou C,Kugler DG,Kilaru G,Nguyen CK,Nagarajan V,Bhairavabhotla RK,Northrup D,Zahr R,Burr P,Liu X,Zhao K,Sher A,Jankovic D,Zhu J,Muljo SA

更新日期：2014-06-19 00:00:00

abstract：:Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which geneti...

journal_title：Immunity

authors： Wakeland EK,Liu K,Graham RR,Behrens TW

更新日期：2001-09-01 00:00:00

abstract：:In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

journal_title：Immunity

authors： Bowie AG

更新日期：2010-09-24 00:00:00

abstract：:In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...

journal_title：Immunity

authors： Villacampa N,Heneka MT

更新日期：2018-02-20 00:00:00

abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...

journal_title：Immunity

authors： Smith TJ,Ducharme LA,Shaw SK,Parker CM,Brenner MB,Kilshaw PJ,Weis JH

更新日期：1994-08-01 00:00:00

abstract：:When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially i...

journal_title：Immunity

authors： Lazear HM,Nice TJ,Diamond MS

更新日期：2015-07-21 00:00:00

abstract：:Notch signaling has been identified as an important regulator of leukocyte differentiation and thymic maturation. Less is known about the role of Notch signaling in regulating mature T cells. We examined the role of Notch 1 in regulating peripheral T cell activity in vitro and in vivo. Coligation of Notch 1 together w...

journal_title：Immunity

authors： Eagar TN,Tang Q,Wolfe M,He Y,Pear WS,Bluestone JA

更新日期：2004-04-01 00:00:00

abstract：:Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...

journal_title：Immunity

authors： Bantug GR,Fischer M,Grählert J,Balmer ML,Unterstab G,Develioglu L,Steiner R,Zhang L,Costa ASH,Gubser PM,Burgener AV,Sauder U,Löliger J,Belle R,Dimeloe S,Lötscher J,Jauch A,Recher M,Hönger G,Hall MN,Romero P,Frez

更新日期：2018-03-20 00:00:00

abstract：:Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...

journal_title：Immunity

authors： Blériot C,Dupuis T,Jouvion G,Eberl G,Disson O,Lecuit M

更新日期：2015-01-20 00:00:00

abstract：:Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...

journal_title：Immunity

authors： Smith LK,Boukhaled GM,Condotta SA,Mazouz S,Guthmiller JJ,Vijay R,Butler NS,Bruneau J,Shoukry NH,Krawczyk CM,Richer MJ

更新日期：2018-02-20 00:00:00

abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

journal_title：Immunity

authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

更新日期：1995-03-01 00:00:00

abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

journal_title：Immunity

authors： Yap GS,Rivera A

更新日期：2012-06-29 00:00:00

abstract：:Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...

journal_title：Immunity

authors： Chavan SS,Pavlov VA,Tracey KJ

更新日期：2017-06-20 00:00:00

abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

journal_title：Immunity

authors： Kioussis D

更新日期：2007-03-01 00:00:00