Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

Abstract:

:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B cells have the capacity to present antigen directly to T cells, owing to the constitutive expression of the accessory molecules B7-1/CD80 and B7-2/CD86. Signals through antigen receptors and CD40 antigen result in these two molecules being further up-regulated more rapidly and strongly on memory B cells than on naive B cells. The unique anatomical localization of memory B cells beneath the surface of mucosa, together with their strong APC capacity, may explain the well-known prompt and robust secondary antibody responses.

journal_name

Immunity

journal_title

Immunity

authors

Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

doi

10.1016/1074-7613(95)90048-9

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

239-48

issue

3

eissn

1074-7613

issn

1097-4180

pii

1074-7613(95)90048-9

journal_volume

2

pub_type

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