Abstract:
:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B cells have the capacity to present antigen directly to T cells, owing to the constitutive expression of the accessory molecules B7-1/CD80 and B7-2/CD86. Signals through antigen receptors and CD40 antigen result in these two molecules being further up-regulated more rapidly and strongly on memory B cells than on naive B cells. The unique anatomical localization of memory B cells beneath the surface of mucosa, together with their strong APC capacity, may explain the well-known prompt and robust secondary antibody responses.
journal_name
Immunityjournal_title
Immunityauthors
Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau Jdoi
10.1016/1074-7613(95)90048-9subject
Has Abstractpub_date
1995-03-01 00:00:00pages
239-48issue
3eissn
1074-7613issn
1097-4180pii
1074-7613(95)90048-9journal_volume
2pub_type
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