Abstract:
:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I-induced proliferation of CD8+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44hi CD8+ (but not CD4+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rbeta on CD8+ cells than on CD4+ cells.
journal_name
Immunityjournal_title
Immunityauthors
Zhang X,Sun S,Hwang I,Tough DF,Sprent Jdoi
10.1016/s1074-7613(00)80564-6subject
Has Abstractpub_date
1998-05-01 00:00:00pages
591-9issue
5eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80564-6journal_volume
8pub_type
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