HSP70 protects against TNF-induced lethal inflammatory shock.


:The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant protection against lethality induced by tumor necrosis factor (TNF). HS prevents high production of interleukin-6 and nitric oxide and reduces severe damage and apoptosis of the enterocytes in the bowel. Mice deficient in the inducible hsp70.1 gene were no longer protected by HS treatment. We show that HS can be applied successfully in an antitumor protocol based on TNF and interferon-gamma, leading to a significant inhibition of lethality but not to a reduction of antitumoral capacity.






Van Molle W,Wielockx B,Mahieu T,Takada M,Taniguchi T,Sekikawa K,Libert C





Has Abstract


2002-05-01 00:00:00
















  • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

    abstract::HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and active antiviral cellular immune responses. In contrast, sooty mangabey monkeys that represent natural hosts for SIV infection do not develop AIDS despite high l...


    pub_type: 杂志文章


    authors: Silvestri G,Sodora DL,Koup RA,Paiardini M,O'Neil SP,McClure HM,Staprans SI,Feinberg MB

    更新日期:2003-03-01 00:00:00

  • Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

    abstract::CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...


    pub_type: 杂志文章


    authors: Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ

    更新日期:2015-03-17 00:00:00

  • Sweet NETs, Bitter Wounds.

    abstract::What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...


    pub_type: 评论,杂志文章


    authors: Papayannopoulos V

    更新日期:2015-08-18 00:00:00

  • Shedding B cell identity.

    abstract::In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state. ...


    pub_type: 评论,杂志文章


    authors: Singh H,Sciammas R

    更新日期:2006-03-01 00:00:00

  • WECHE: a novel hematopoietic regulatory factor.

    abstract::Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...


    pub_type: 杂志文章


    authors: Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

    更新日期:2000-02-01 00:00:00

  • Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

    abstract::Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...


    pub_type: 杂志文章


    authors: Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

    更新日期:2011-10-28 00:00:00

  • Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.

    abstract::Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...


    pub_type: 杂志文章


    authors: Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

    更新日期:2020-02-18 00:00:00

  • A Shocking Type of Communication.

    abstract::In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis....


    pub_type: 评论,杂志文章


    authors: Sallis BF,Fiebiger E

    更新日期:2018-12-18 00:00:00

  • Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

    abstract::CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the ou...


    pub_type: 杂志文章


    authors: Schwartz DM,Farley TK,Richoz N,Yao C,Shih HY,Petermann F,Zhang Y,Sun HW,Hayes E,Mikami Y,Jiang K,Davis FP,Kanno Y,Milner JD,Siegel R,Laurence A,Meylan F,O'Shea JJ

    更新日期:2019-01-15 00:00:00

  • A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells.

    abstract::Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...


    pub_type: 杂志文章


    authors: Ackerman AL,Giodini A,Cresswell P

    更新日期:2006-10-01 00:00:00

  • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.

    abstract::A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...


    pub_type: 杂志文章


    authors: Shrikant P,Khoruts A,Mescher MF

    更新日期:1999-10-01 00:00:00

  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

    abstract::Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...


    pub_type: 杂志文章


    authors: Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

    更新日期:1997-04-01 00:00:00

  • Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.

    abstract::Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...


    pub_type: 杂志文章,评审


    authors: Colonna M

    更新日期:2009-07-17 00:00:00

  • CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

    abstract::CD4(+)CD25(+) immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function. We analyzed CD4(+)CD25(+) and CD4(+)CD25(-) T cells by DNA microarray, identifying 29 genes differentially expressed in the resting subpopulations, and 77...


    pub_type: 杂志文章


    authors: McHugh RS,Whitters MJ,Piccirillo CA,Young DA,Shevach EM,Collins M,Byrne MC

    更新日期:2002-02-01 00:00:00

  • Targeting Immune Cell Wiring in Ulcerative Colitis.

    abstract::The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research. ...


    pub_type: 评论,杂志文章


    authors: Neurath MF,Chiriac MT

    更新日期:2019-11-19 00:00:00

  • Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

    abstract::NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...


    pub_type: 杂志文章


    authors: Brydges SD,Mueller JL,McGeough MD,Pena CA,Misaghi A,Gandhi C,Putnam CD,Boyle DL,Firestein GS,Horner AA,Soroosh P,Watford WT,O'Shea JJ,Kastner DL,Hoffman HM

    更新日期:2009-06-19 00:00:00

  • Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity.

    abstract::Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...


    pub_type: 杂志文章


    authors: Yatim N,Albert ML

    更新日期:2011-10-28 00:00:00

  • "Dangerous crystals".

    abstract::Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...


    pub_type: 评论,杂志文章


    authors: DeFranco AL

    更新日期:2008-11-14 00:00:00

  • Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.

    abstract::Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associ...


    pub_type: 杂志文章


    authors: Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS

    更新日期:2018-12-18 00:00:00

  • Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.

    abstract::Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...


    pub_type: 杂志文章


    authors: Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

    更新日期:1998-11-01 00:00:00

  • Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

    abstract::The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...


    pub_type: 杂志文章


    authors: Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

    更新日期:2018-06-19 00:00:00

  • Dysfunctional HDL takes its toll in chronic kidney disease.

    abstract::Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism. ...


    pub_type: 评论,杂志文章


    authors: Moore KJ,Fisher EA

    更新日期:2013-04-18 00:00:00

  • Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome.

    abstract::Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...


    pub_type: 杂志文章


    authors: Guo C,Xie S,Chi Z,Zhang J,Liu Y,Zhang L,Zheng M,Zhang X,Xia D,Ke Y,Lu L,Wang D

    更新日期:2016-10-18 00:00:00

  • T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76.

    abstract::Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...


    pub_type: 杂志文章


    authors: Nguyen K,Sylvain NR,Bunnell SC

    更新日期:2008-06-01 00:00:00

  • The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

    abstract::Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...


    pub_type: 杂志文章


    authors: Yang S,Wang B,Humphries F,Hogan AE,O'Shea D,Moynagh PN

    更新日期:2014-12-18 00:00:00

  • Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.

    abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...


    pub_type: 杂志文章


    authors: Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

    更新日期:1996-04-01 00:00:00

  • Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules.

    abstract::Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...


    pub_type: 杂志文章


    authors: Day PM,Esquivel F,Lukszo J,Bennink JR,Yewdell JW

    更新日期:1995-02-01 00:00:00

  • Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

    abstract::The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...


    pub_type: 杂志文章


    authors: Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

    更新日期:2002-10-01 00:00:00

  • IL-2: Change Structure … Change Function.

    abstract::In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...


    pub_type: 评论,杂志文章


    authors: Bluestone JA,Crellin N,Trotta E

    更新日期:2015-05-19 00:00:00

  • The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

    abstract::To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...


    pub_type: 杂志文章


    authors: Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

    更新日期:2002-09-01 00:00:00