HSP70 protects against TNF-induced lethal inflammatory shock.

Abstract:

:The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant protection against lethality induced by tumor necrosis factor (TNF). HS prevents high production of interleukin-6 and nitric oxide and reduces severe damage and apoptosis of the enterocytes in the bowel. Mice deficient in the inducible hsp70.1 gene were no longer protected by HS treatment. We show that HS can be applied successfully in an antitumor protocol based on TNF and interferon-gamma, leading to a significant inhibition of lethality but not to a reduction of antitumoral capacity.

journal_name

Immunity

journal_title

Immunity

authors

Van Molle W,Wielockx B,Mahieu T,Takada M,Taniguchi T,Sekikawa K,Libert C

doi

10.1016/s1074-7613(02)00310-2

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

685-95

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00310-2

journal_volume

16

pub_type

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