Abstract:
:The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant protection against lethality induced by tumor necrosis factor (TNF). HS prevents high production of interleukin-6 and nitric oxide and reduces severe damage and apoptosis of the enterocytes in the bowel. Mice deficient in the inducible hsp70.1 gene were no longer protected by HS treatment. We show that HS can be applied successfully in an antitumor protocol based on TNF and interferon-gamma, leading to a significant inhibition of lethality but not to a reduction of antitumoral capacity.
journal_name
Immunityjournal_title
Immunityauthors
Van Molle W,Wielockx B,Mahieu T,Takada M,Taniguchi T,Sekikawa K,Libert Cdoi
10.1016/s1074-7613(02)00310-2keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
685-95issue
5eissn
1074-7613issn
1097-4180pii
S1074-7613(02)00310-2journal_volume
16pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::Using a transgenic approach, we examined distal regulatory elements located in the IL-4 locus and the role of GATA-3 at these elements. The intergenic DNase I hypersensitive sites (HSS) showed strong enhancement, and the intronic enhancer (IE) and HS5/HS5a sites showed weaker enhancement of the IL-4 promoter. Elements...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00125-x
更新日期:2001-04-01 00:00:00
abstract::Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2005.11.010
更新日期:2006-01-01 00:00:00
abstract::Mouse blood monocytes include two main subsets usually discriminated by the expression of the Ly6C surface marker. The study by Mildner et al. (2017) in this issue of Immunity clarifies the transcriptional circuits controlling the generation of Ly6C- cells from their obligate precursors, the Ly6C+ monocytes. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.04.010
更新日期:2017-05-16 00:00:00
abstract::The investigation of gammadelta T cells has identified a rapid lymphoid stress-surveillance response to microbial and nonmicrobial tissue perturbation. In addition to providing local protection, this response provides an immediate source of cytokines, chemokines, and other functions that can substantially affect downs...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.08.006
更新日期:2009-08-21 00:00:00
abstract::Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.01.010
更新日期:2014-03-20 00:00:00
abstract::Tissue-resident mast cells are associated with many inflammatory and physiological processes. Although mast cells arise from the yolk sac, the exact ontogeny of adult mast cells remains unclear. Here we have investigated the hematopoietic origin of mast cells using fate-mapping systems. We have shown that early erythr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.09.023
更新日期:2018-10-16 00:00:00
abstract::Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.01.023
更新日期:2016-02-16 00:00:00
abstract::Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.03.001
更新日期:2015-03-17 00:00:00
abstract::Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.03.011
更新日期:2011-03-25 00:00:00
abstract::CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00363-1
更新日期:2002-08-01 00:00:00
abstract::Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signali...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80211-3
更新日期:2000-06-01 00:00:00
abstract::Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.02.007
更新日期:2020-03-17 00:00:00
abstract::The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimatel...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.08.011
更新日期:2020-09-15 00:00:00
abstract::Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well defined. To identify the global regulatory networks controlling antigen presentation, we employed genome-wide screening in human di...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.11.002
更新日期:2021-01-12 00:00:00
abstract::Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.07.017
更新日期:2012-11-16 00:00:00
abstract::The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.016
更新日期:2016-09-20 00:00:00
abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90010-8
更新日期:1994-04-01 00:00:00
abstract::Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.019
更新日期:2008-06-01 00:00:00
abstract::T cell activation is tightly regulated to avoid autoimmunity. Gene related to anergy in lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell tolerance. Here, we generated and analyzed GRAIL-deficient mice and found they were resistant to immune tolerance induction and exhibited great...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.05.002
更新日期:2010-05-28 00:00:00
abstract::Phosphatidylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at several B cell developmental stages. We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.10.021
更新日期:2015-12-15 00:00:00
abstract::CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the ou...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.014
更新日期:2019-01-15 00:00:00
abstract::The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived from a nonmutagenized control animal) is helping to dissect a now resurgent area of immunology. Despite a vast literature during the 1970s, the study of suppre...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(03)00207-3
更新日期:2003-08-01 00:00:00
abstract::Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We investigated the mechanism that lipopolysaccharide (LPS) induces early neutrophil recruitment to lungs and increases pulmonary vascular permeability during ALI. Intr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.03.007
更新日期:2015-04-21 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.11.013
更新日期:2007-12-01 00:00:00
abstract::The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we s...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.01.016
更新日期:2012-03-23 00:00:00
abstract::Perforin-mediated cytotoxicity is essential for clearance of primary LCMV infection. BALB/c-perforin-deficient (PKO) mice survived LCMV infection by deleting NP(118)-specific CD8(+) T cells whereas vaccination of PKO mice with Listeria expressing NP(118) generated a stable memory CD8(+) T cell population. However, >85...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00079-7
更新日期:2003-04-01 00:00:00
abstract::Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.06.011
更新日期:2015-07-21 00:00:00
abstract::Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.10.010
更新日期:2011-10-28 00:00:00
abstract::Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00013-3
更新日期:2000-07-01 00:00:00