Abstract：
:CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the outcome of the immune response. We examined the impact of RA on the genome-wide transcriptional response during Th differentiation to multiple subsets. RA effects were subset-selective and were most significant in Th9 cells. RA globally antagonized Th9-promoting transcription factors and inhibited Th9 differentiation. RA directly targeted the extended Il9 locus and broadly modified the Th9 epigenome through RARα. RA-RARα activity limited murine Th9-associated pulmonary inflammation, and human allergic inflammation was associated with reduced expression of RA target genes. Thus, repression of the Th9 program is a major function of RA-RARα signaling in Th differentiation, arguing for a role for RA in interleukin 9 (IL-9) related diseases.
journal_name
Immunityjournal_title
Immunityauthors
Schwartz DM,Farley TK,Richoz N,Yao C,Shih HY,Petermann F,Zhang Y,Sun HW,Hayes E,Mikami Y,Jiang K,Davis FP,Kanno Y,Milner JD,Siegel R,Laurence A,Meylan F,O'Shea JJdoi
10.1016/j.immuni.2018.12.014subject
Has Abstractpub_date
2019-01-15 00:00:00pages
106-120.e10issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(18)30562-4journal_volume
50pub_type
杂志文章相关文献
IMMUNITY文献大全abstract：:The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2017.04.002
更新日期：2017-04-18 00:00:00
abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.06.012
更新日期：2020-07-14 00:00:00
abstract：:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.03.018
更新日期：2019-04-16 00:00:00
abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.07.007
更新日期：2016-08-16 00:00:00
abstract：:The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90146-9
更新日期：1995-04-01 00:00:00
abstract：:Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. R...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2015.04.005
更新日期：2015-04-21 00:00:00
abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00262-5
更新日期：2002-01-01 00:00:00
abstract：:Caspases are intracellular proteases that mediate mammalian cell apoptosis. Caspase-1 (Casp-1) is a unique caspase because it activates the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Shigella flexneri, the etiological agent of bacillary dysentery, induces macrophage apoptosis, which requires Casp-1 an...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80209-5
更新日期：2000-05-01 00:00:00
abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2017.01.004
更新日期：2017-02-21 00:00:00
abstract：:To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(94)90010-8
更新日期：1994-04-01 00:00:00
abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2006.07.006
更新日期：2006-07-01 00:00:00
abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.02.007
更新日期：2020-03-17 00:00:00
abstract：:Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(01)00150-9
更新日期：2001-06-01 00:00:00
abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2019.12.015
更新日期：2020-01-14 00:00:00
abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2012.10.012
更新日期：2012-11-16 00:00:00
abstract：:Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.05.020
更新日期：2019-06-18 00:00:00
abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2007.03.009
更新日期：2007-04-01 00:00:00
abstract：:The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2011.01.013
更新日期：2011-03-25 00:00:00
abstract：:Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and e...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2017.10.015
更新日期：2017-11-21 00:00:00
abstract：:In this issue of Immunity, Jiang et al. (2011) provide evidence that the CD8 coreceptor is recruited to the T cell receptor (TCR) complex after initial TCR triggering where it stabilizes the TCR-peptide-major histocompatibility complex interaction. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2011.01.001
更新日期：2011-01-28 00:00:00
abstract：:Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(95)80014-x
更新日期：1995-02-01 00:00:00
abstract：:The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80034-5
更新日期：1999-03-01 00:00:00
abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.08.007
更新日期：2015-09-15 00:00:00
abstract：:Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/s1074-7613(03)00303-0
更新日期：2003-11-01 00:00:00
abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80130-2
更新日期：1999-11-01 00:00:00
abstract：:To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00394-1
更新日期：2002-09-01 00:00:00
abstract：:Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.12.006
更新日期：2016-01-19 00:00:00
abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.01.017
更新日期：2015-02-17 00:00:00
abstract：:We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V re...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80471-9
更新日期：1998-02-01 00:00:00
