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Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation.

Abstract：

:Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improve transcriptional analysis in immunology, we created ImmuneSigDB: a manually annotated compendium of ∼5,000 gene-sets from diverse cell states, experimental manipulations, and genetic perturbations in immunology. Analysis using ImmuneSigDB identified signatures induced in activated myeloid cells and differentiating lymphocytes that were highly conserved between humans and mice. Sepsis triggered conserved patterns of gene expression in humans and mouse models. However, we also identified species-specific biological processes in the sepsis transcriptional response: although both species upregulated phagocytosis-related genes, a mitosis signature was specific to humans. ImmuneSigDB enables granular analysis of transcriptomic data to improve biological understanding of immune processes of the human and mouse immune systems.

journal_name

Immunity

journal_title

Immunity

authors

Godec J,Tan Y,Liberzon A,Tamayo P,Bhattacharya S,Butte AJ,Mesirov JP,Haining WN

doi

10.1016/j.immuni.2015.12.006

subject

Has Abstract

pub_date

2016-01-19 00:00:00

pages

194-206

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(15)00532-4

journal_volume

44

pub_type

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