Abstract:
:Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the concerted action of a cohort of accessory molecules that includes chaperones, transporters of peptides, and the proteases that degrade the antigens.
journal_name
Immunityjournal_title
Immunityauthors
Villadangos JA,Ploegh HLdoi
10.1016/s1074-7613(00)80176-4keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
233-9issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80176-4journal_volume
12pub_type
杂志文章,评审相关文献
IMMUNITY文献大全abstract::Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00279-0
更新日期:2002-02-01 00:00:00
abstract::The skin barrier is essential for host defense, but how the skin provides protection when the barrier is breached is not well understood. In this issue of Immunity, Gallo and colleagues report that keratinocytes integrate signals from antimicrobial peptides via MAVS signaling to amplify their antiviral immune response...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.07.001
更新日期:2016-07-19 00:00:00
abstract::Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00013-3
更新日期:2000-07-01 00:00:00
abstract::Superantigens (SAGs) activate T cells by simultaneously binding the Vbeta domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Valpha regions among SAG-reactive T cells has suggested that the TCR alpha chain may modulate the level of activation through an int...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80047-3
更新日期:1999-04-01 00:00:00
abstract::The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived from a nonmutagenized control animal) is helping to dissect a now resurgent area of immunology. Despite a vast literature during the 1970s, the study of suppre...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(03)00207-3
更新日期:2003-08-01 00:00:00
abstract::Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2013.07.008
更新日期:2013-07-25 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.07.009
更新日期:2015-08-18 00:00:00
abstract::Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.11.005
更新日期:2018-11-20 00:00:00
abstract::The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in their HLA class I and KIR genes. More than 98% of the clones were inhibited by individual autologous class I allotypes, and every clone was inhibited by the combin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80393-3
更新日期:1997-12-01 00:00:00
abstract::Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2013.07.017
更新日期:2013-08-22 00:00:00
abstract::T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Depending on the pattern of HEL expression, deletion of double-positive thymocytes ranged from minimal to complete, and peripheral ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80528-2
更新日期:1997-08-01 00:00:00
abstract::Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00281-9
更新日期:2002-03-01 00:00:00
abstract::Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.08.015
更新日期:2011-10-28 00:00:00
abstract::It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.11.002
更新日期:2011-11-23 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90131-0
更新日期:1995-11-01 00:00:00
abstract::The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00419-3
更新日期:2002-10-01 00:00:00
abstract::Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.10.001
更新日期:2017-10-17 00:00:00
abstract::Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.12.029
更新日期:2015-01-20 00:00:00
abstract::In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2013.03.001
更新日期:2013-03-21 00:00:00
abstract::What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.08.002
更新日期:2015-08-18 00:00:00
abstract::Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80592-0
更新日期:1998-07-01 00:00:00
abstract::Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.12.001
更新日期:2017-12-19 00:00:00
abstract::The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not pr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90102-3
更新日期:1994-05-01 00:00:00
abstract::Apoptotic death of T lymphocytes is critical for shutdown of immune responses and hemopoietic cell homeostasis. Both death receptor (Fas) activation and mitochondrial apoptosis triggered by the BH3-only protein Bim have been implicated in the killing of antigen-stimulated T cells. We examined mice lacking the gene enc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.12.017
更新日期:2008-02-01 00:00:00
abstract::T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.12.006
更新日期:2008-01-01 00:00:00
abstract::Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90013-6
更新日期:1995-06-01 00:00:00
abstract::We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.023
更新日期:2018-04-17 00:00:00
abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80249-6
更新日期:1996-04-01 00:00:00
abstract::Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.07.014
更新日期:2018-10-16 00:00:00