Abstract：
:Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interferon-gamma. Specific inhibition of cathepsin S in B lymphoblastoid cells prevented complete proteolysis of li, resulting in accumulation of a class II-associated 13 kDa li fragment in vivo. Consequently, the formation of SDS-stable complexes was markedly reduced. Purified cathepsin S, but not cathepsin B, H, or D, specifically digested li from alpha beta li trimers, generating alpha beta-CLIP complexes capable of binding exogenously added peptide in vitro. Thus, cathepsin S is essential in B cells for effective li proteolysis necessary to render class II molecules competent for binding peptides.
journal_name
Immunityjournal_title
Immunityauthors
Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HAdoi
10.1016/s1074-7613(00)80249-6subject
Has Abstractpub_date
1996-04-01 00:00:00pages
357-66issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80249-6journal_volume
4pub_type
杂志文章相关文献
IMMUNITY文献大全abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.07.001
更新日期：2010-07-23 00:00:00
abstract：:Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2018.05.015
更新日期：2018-06-19 00:00:00
abstract：:Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(01)00246-1
更新日期：2001-12-01 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2012.08.015
更新日期：2012-10-19 00:00:00
abstract：:We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and are highly susceptible to abscess formation by gram-positive bacteria. Arrested, morphologically atypical, Gr1(+)Mac1(+) myeloid cells expand with age in the bone marrow...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00501-0
更新日期：2003-01-01 00:00:00
abstract：:As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.11.017
更新日期：2019-01-15 00:00:00
abstract：:By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL failed to lyse autologous EBV-transformed B cells, even though the latter express the protein. This is due to the presence in these cells of immunoproteasomes, w...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80163-6
更新日期：2000-01-01 00:00:00
abstract：:Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiatio...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80443-4
更新日期：1997-06-01 00:00:00
abstract：:Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.02.007
更新日期：2020-03-17 00:00:00
abstract：:Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2012.04.015
更新日期：2012-08-24 00:00:00
abstract：:The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells. Here, we show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma. Such IFN-gamma production was transc...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.04.004
更新日期：2010-04-23 00:00:00
abstract：:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(01)00210-2
更新日期：2001-10-01 00:00:00
abstract：:Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced loss of Notch1 functio...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80054-0
更新日期：1999-05-01 00:00:00
abstract：:Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2014.04.014
更新日期：2014-05-15 00:00:00
abstract：:Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the c...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/s1074-7613(00)80176-4
更新日期：2000-03-01 00:00:00
abstract：:The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth facto...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2019.01.008
更新日期：2019-03-19 00:00:00
abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2019.12.015
更新日期：2020-01-14 00:00:00
abstract：:Anopheles gambiae uses effective immune responses, including phagocytosis, to fight microbial infection. We have developed a semiquantitative phagocytosis test and used it in conjunction with dsRNA gene silencing to test the in vivo roles of 71 candidate genes in phagocytosis of Escherichia coli and Staphylococcus aur...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2005.05.006
更新日期：2005-07-01 00:00:00
abstract：:Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appropriate immune response. To initiate responses to highly disparate challenges, DCs have diversified into multiple phenotypically, anatomically, and functionally distinct cell types. As a res...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2020.05.005
更新日期：2020-06-16 00:00:00
abstract：:Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological types. However, such immunotherapies fail to control neoplasia in a significant proportion of patients. Here, we review how a range of cancer-cell-autonomous cue...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2016.06.001
更新日期：2016-06-21 00:00:00
abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80199-5
更新日期：2000-05-01 00:00:00
abstract：:B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(94)80021-9
更新日期：1994-12-01 00:00:00
abstract：:Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(95)80014-x
更新日期：1995-02-01 00:00:00
abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2015.03.001
更新日期：2015-03-17 00:00:00
abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2020.03.007
更新日期：2020-04-14 00:00:00
abstract：:We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.03.023
更新日期：2018-04-17 00:00:00
abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2012.06.007
更新日期：2012-06-29 00:00:00
abstract：:Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health. HIV-infected adults have excess risk of cardiovascular, liver, kidney, bone, and neurologic diseases. Many markers of inflammation are elevated in HIV di...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2013.10.001
更新日期：2013-10-17 00:00:00
abstract：:Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2015.12.019
更新日期：2016-01-19 00:00:00
abstract：:Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.12.006
更新日期：2016-01-19 00:00:00
