Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way.

Abstract:

:Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state.

journal_name

Immunity

journal_title

Immunity

authors

Schultze JL,Beyer M

doi

10.1016/j.immuni.2015.12.019

subject

Has Abstract

pub_date

2016-01-19 00:00:00

pages

18-20

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(15)00545-2

journal_volume

44

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Sweet NETs, Bitter Wounds.

    abstract::What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2015.08.002

    authors: Papayannopoulos V

    更新日期:2015-08-18 00:00:00

  • The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

    abstract::The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable T cell function remains unclear. Here, we report that T cells lacking both Bax and Bak display defects in antigen-specific proliferation because of Ca(2+)-sign...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2007.05.023

    authors: Jones RG,Bui T,White C,Madesh M,Krawczyk CM,Lindsten T,Hawkins BJ,Kubek S,Frauwirth KA,Wang YL,Conway SJ,Roderick HL,Bootman MD,Shen H,Foskett JK,Thompson CB

    更新日期:2007-08-01 00:00:00

  • Formin the way.

    abstract::Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

    journal_title:Immunity

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.immuni.2007.02.007

    authors: Schwartzberg PL

    更新日期:2007-02-01 00:00:00

  • Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

    abstract::Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2011.06.009

    authors: Garg S,Sharma M,Ung C,Tuli A,Barral DC,Hava DL,Veerapen N,Besra GS,Hacohen N,Brenner MB

    更新日期:2011-08-26 00:00:00

  • The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.

    abstract::A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor ce...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80457-4

    authors: Li L,Milner LA,Deng Y,Iwata M,Banta A,Graf L,Marcovina S,Friedman C,Trask BJ,Hood L,Torok-Storb B

    更新日期:1998-01-01 00:00:00

  • How do adjuvants work? Important considerations for new generation adjuvants.

    abstract::In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2007.11.003

    authors: McKee AS,Munks MW,Marrack P

    更新日期:2007-11-01 00:00:00

  • Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

    abstract::The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80064-3

    authors: Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

    更新日期:1999-06-01 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.10.011

    authors: Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期:2018-12-18 00:00:00

  • Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.

    abstract::Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00300-x

    authors: Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

    更新日期:2002-04-01 00:00:00

  • Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.

    abstract::Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.09.014

    authors: Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

    更新日期:2012-12-14 00:00:00

  • Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.

    abstract::Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80082-5

    authors: Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DH

    更新日期:1999-07-01 00:00:00

  • "Dangerous crystals".

    abstract::Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2008.10.005

    authors: DeFranco AL

    更新日期:2008-11-14 00:00:00

  • A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

    abstract::The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth facto...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.01.008

    authors: Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM

    更新日期:2019-03-19 00:00:00

  • Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

    abstract::Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2',5' cGAMP, that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates to the nucleus and initiates the transcription...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.10.019

    authors: Li X,Shu C,Yi G,Chaton CT,Shelton CL,Diao J,Zuo X,Kao CC,Herr AB,Li P

    更新日期:2013-12-12 00:00:00

  • Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

    abstract::Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that granzyme B initiates caspase processing but cannot fully process procaspase-3 in intact Jurkat T leukemia or NT2 neuronal cells. Rather, the release from mitochondria of proapoptotic mediators ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(03)00050-5

    authors: Sutton VR,Wowk ME,Cancilla M,Trapani JA

    更新日期:2003-03-01 00:00:00

  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.

    abstract::Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.02.007

    authors: Fukushima K,Satoh T,Sugihara F,Sato Y,Okamoto T,Mitsui Y,Yoshio S,Li S,Nojima S,Motooka D,Nakamura S,Kida H,Standley DM,Morii E,Kanto T,Yanagita M,Matsuura Y,Nagasawa T,Kumanogoh A,Akira S

    更新日期:2020-03-17 00:00:00

  • Treg cells acquire new directions, cytokines navigate.

    abstract::Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.09.004

    authors: Ohkura N,Sakaguchi S

    更新日期:2012-09-21 00:00:00

  • Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

    abstract::Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyroph...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90178-7

    authors: Morita CT,Beckman EM,Bukowski JF,Tanaka Y,Band H,Bloom BR,Golan DE,Brenner MB

    更新日期:1995-10-01 00:00:00

  • Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals.

    abstract::The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.04.023

    authors: Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

    更新日期:2020-06-16 00:00:00

  • The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

    abstract::The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) respo...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.02.004

    authors: Carroll EC,Jin L,Mori A,Muñoz-Wolf N,Oleszycka E,Moran HBT,Mansouri S,McEntee CP,Lambe E,Agger EM,Andersen P,Cunningham C,Hertzog P,Fitzgerald KA,Bowie AG,Lavelle EC

    更新日期:2016-03-15 00:00:00

  • Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

    abstract::The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2006.08.018

    authors: Gangadharan D,Lambolez F,Attinger A,Wang-Zhu Y,Sullivan BA,Cheroutre H

    更新日期:2006-10-01 00:00:00

  • GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

    abstract::The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.03.022

    authors: Dougan M,Dranoff G,Dougan SK

    更新日期:2019-04-16 00:00:00

  • In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos.

    abstract::We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from embryos. Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+). Thus defined, EC population takes up acetylated LDL and co...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80581-6

    authors: Nishikawa SI,Nishikawa S,Kawamoto H,Yoshida H,Kizumoto M,Kataoka H,Katsura Y

    更新日期:1998-06-01 00:00:00

  • Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses.

    abstract::Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2017.03.015

    authors: Konkel JE,Zhang D,Zanvit P,Chia C,Zangarle-Murray T,Jin W,Wang S,Chen W

    更新日期:2017-04-18 00:00:00

  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.

    abstract::Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of T...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.04.016

    authors: Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT

    更新日期:2010-05-28 00:00:00

  • TRAF3: uncovering the real but restricted role in human.

    abstract::In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2010.09.008

    authors: Bowie AG

    更新日期:2010-09-24 00:00:00

  • Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.

    abstract::La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.02.013

    authors: Mukherjee P,Woods TA,Moore RA,Peterson KE

    更新日期:2013-04-18 00:00:00

  • SHIP modulates immune receptor responses by regulating membrane association of Btk.

    abstract::Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either Fc...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80555-5

    authors: Bolland S,Pearse RN,Kurosaki T,Ravetch JV

    更新日期:1998-04-01 00:00:00

  • Toll signaling in flies and mammals: two sorts of MyD88.

    abstract::The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.04.001

    authors: Goto A,Imler JL

    更新日期:2012-04-20 00:00:00

  • Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.

    abstract::T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2009.07.009

    authors: Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

    更新日期:2009-10-16 00:00:00