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The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.

Abstract：

:A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor cells. G-CSF-induced differentiation of 32D cells expressing Notch1 was inhibited by coculturing with HS-27a. A peptide corresponding to the Delta/Serrate/LAG-2 domain of hJagged1 and supernatants from COS cells expressing a soluble form of the extracellular portion of hJagged1 were able to mimic this effect. These observations suggest that hJagged1 may function as a ligand for Notch1 and play a role in mediating cell fate decisions during hematopoiesis.

journal_name

Immunity

journal_title

Immunity

authors

Li L,Milner LA,Deng Y,Iwata M,Banta A,Graf L,Marcovina S,Friedman C,Trask BJ,Hood L,Torok-Storb B

doi

10.1016/s1074-7613(00)80457-4

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

43-55

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80457-4

journal_volume

8

pub_type

杂志文章

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