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Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.

Abstract：

:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiting T helper 2 responses. Whereas stimulated T cells from wild-type mice show a transient increase and then a rapid decline in the steady-state levels of IL-4 mRNA in vitro, the levels of IL-4 gene transcripts in NFAT1-deficient T cells are maintained at high levels under the same conditions. Consistent with this observation, NFAT1-/- mice are more susceptible to infection with Leishmania major. This report provides evidence that NFAT proteins regulate not only the initiation but also the termination of gene transcription.

journal_name

Immunity

journal_title

Immunity

authors

Kiani A,Viola JP,Lichtman AH,Rao A

doi

10.1016/s1074-7613(00)80403-3

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

849-60

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80403-3

journal_volume

7

pub_type

杂志文章

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