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Immune responses to the microbiota at the intestinal mucosal surface.

Abstract：

:The mammalian intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. These microbes establish symbiotic relationships with their hosts, making important contributions to metabolism and digestive efficiency. The intestinal epithelial surface is the primary interface between the vast microbiota and internal host tissues. Given the enormous numbers of enteric bacteria and the persistent threat of opportunistic invasion, it is crucial that mammalian hosts monitor and regulate microbial interactions with intestinal epithelial surfaces. Here we discuss recent insights into how the innate and adaptive arms of the immune system collaborate to maintain homeostasis at the luminal surface of the intestinal host-microbial interface. These findings are also yielding a better understanding of how symbiotic host-microbial relationships can break down in inflammatory bowel disease.

journal_name

Immunity

journal_title

Immunity

authors

Duerkop BA,Vaishnava S,Hooper LV

doi

10.1016/j.immuni.2009.08.009

subject

Has Abstract

pub_date

2009-09-18 00:00:00

pages

368-76

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(09)00367-7

journal_volume

31

pub_type

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