Plague's partners in crime.

Abstract:

:The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopathy.

journal_name

Immunity

journal_title

Immunity

authors

Davis KM,Isberg RR

doi

10.1016/j.immuni.2014.09.003

subject

Has Abstract

pub_date

2014-09-18 00:00:00

pages

347-349

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(14)00314-8

journal_volume

41

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae.

    abstract::Anopheles gambiae uses effective immune responses, including phagocytosis, to fight microbial infection. We have developed a semiquantitative phagocytosis test and used it in conjunction with dsRNA gene silencing to test the in vivo roles of 71 candidate genes in phagocytosis of Escherichia coli and Staphylococcus aur...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2005.05.006

    authors: Moita LF,Wang-Sattler R,Michel K,Zimmermann T,Blandin S,Levashina EA,Kafatos FC

    更新日期:2005-07-01 00:00:00

  • Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

    abstract::The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80064-3

    authors: Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

    更新日期:1999-06-01 00:00:00

  • Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.

    abstract::Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β secretion without cell death, but what controls these different outcomes is unknown. Here, we show...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.04.005

    authors: Carty M,Kearney J,Shanahan KA,Hams E,Sugisawa R,Connolly D,Doran CG,Muñoz-Wolf N,Gürtler C,Fitzgerald KA,Lavelle EC,Fallon PG,Bowie AG

    更新日期:2019-06-18 00:00:00

  • The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.

    abstract::The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80602-0

    authors: Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

    更新日期:1998-08-01 00:00:00

  • Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

    abstract::Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.01.006

    authors: Smith LK,Boukhaled GM,Condotta SA,Mazouz S,Guthmiller JJ,Vijay R,Butler NS,Bruneau J,Shoukry NH,Krawczyk CM,Richer MJ

    更新日期:2018-02-20 00:00:00

  • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

    abstract::Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.08.015

    authors: Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

    更新日期:2012-10-19 00:00:00

  • The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

    abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2009.02.005

    authors: Allen IC,Scull MA,Moore CB,Holl EK,McElvania-TeKippe E,Taxman DJ,Guthrie EH,Pickles RJ,Ting JP

    更新日期:2009-04-17 00:00:00

  • Proteolysis in MHC class II antigen presentation: who's in charge?

    abstract::Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the c...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/s1074-7613(00)80176-4

    authors: Villadangos JA,Ploegh HL

    更新日期:2000-03-01 00:00:00

  • Class-Switch Recombination Occurs Infrequently in Germinal Centers.

    abstract::Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.07.001

    authors: Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG

    更新日期:2019-08-20 00:00:00

  • Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

    abstract::CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give pr...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2009.03.022

    authors: Im JS,Arora P,Bricard G,Molano A,Venkataswamy MM,Baine I,Jerud ES,Goldberg MF,Baena A,Yu KO,Ndonye RM,Howell AR,Yuan W,Cresswell P,Chang YT,Illarionov PA,Besra GS,Porcelli SA

    更新日期:2009-06-19 00:00:00

  • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.

    abstract::The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2009.10.010

    authors: Rao RR,Li Q,Odunsi K,Shrikant PA

    更新日期:2010-01-29 00:00:00

  • miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression.

    abstract::Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.03.014

    authors: Escobar TM,Kanellopoulou C,Kugler DG,Kilaru G,Nguyen CK,Nagarajan V,Bhairavabhotla RK,Northrup D,Zahr R,Burr P,Liu X,Zhao K,Sher A,Jankovic D,Zhu J,Muljo SA

    更新日期:2014-06-19 00:00:00

  • AMPK helps T cells survive nutrient starvation.

    abstract::Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.12.029

    authors: Yang K,Chi H

    更新日期:2015-01-20 00:00:00

  • Treg cells acquire new directions, cytokines navigate.

    abstract::Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.09.004

    authors: Ohkura N,Sakaguchi S

    更新日期:2012-09-21 00:00:00

  • Microglia Get a Little Help from "Th"-eir Friends.

    abstract::The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimatel...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.08.011

    authors: Locatelli G,Engelhardt B

    更新日期:2020-09-15 00:00:00

  • Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined.

    abstract::Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90162-0

    authors: Bargatze RF,Jutila MA,Butcher EC

    更新日期:1995-07-01 00:00:00

  • The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.

    abstract::The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2006.10.013

    authors: Chen C,Huang X,Atakilit A,Zhu QS,Corey SJ,Sheppard D

    更新日期:2006-12-01 00:00:00

  • Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.

    abstract::The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.07.005

    authors: Boudreau JE,Liu XR,Zhao Z,Zhang A,Shultz LD,Greiner DL,Dupont B,Hsu KC

    更新日期:2016-08-16 00:00:00

  • Regulatory T cells and inflammation: better late than never.

    abstract::In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation. ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.07.001

    authors: Ziegler SF

    更新日期:2008-07-18 00:00:00

  • The Miami Monkey: A Sunny Alternative to the Berlin Patient.

    abstract::Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2019.02.010

    authors: Liberatore RA,Ho DD

    更新日期:2019-03-19 00:00:00

  • Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.

    abstract::La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.02.013

    authors: Mukherjee P,Woods TA,Moore RA,Peterson KE

    更新日期:2013-04-18 00:00:00

  • TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.

    abstract::Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.04.015

    authors: Pilli M,Arko-Mensah J,Ponpuak M,Roberts E,Master S,Mandell MA,Dupont N,Ornatowski W,Jiang S,Bradfute SB,Bruun JA,Hansen TE,Johansen T,Deretic V

    更新日期:2012-08-24 00:00:00

  • SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis.

    abstract::Fc gammaRIIB is an inhibitory receptor that terminates activation signals initiated by antigen cross-linking of the BCR through the recruitment of SHIP. Fc gammaRIIB can also signal independently of BCR coligation to directly mediate an apoptotic response, requiring only an intact transmembrane domain. Failure to recr...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80074-6

    authors: Pearse RN,Kawabe T,Bolland S,Guinamard R,Kurosaki T,Ravetch JV

    更新日期:1999-06-01 00:00:00

  • Caspase-8: clipping off RIG-I signaling.

    abstract::Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2011.03.011

    authors: Roth S,Ruland J

    更新日期:2011-03-25 00:00:00

  • Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

    abstract::The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we s...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.01.016

    authors: Roberts NA,White AJ,Jenkinson WE,Turchinovich G,Nakamura K,Withers DR,McConnell FM,Desanti GE,Benezech C,Parnell SM,Cunningham AF,Paolino M,Penninger JM,Simon AK,Nitta T,Ohigashi I,Takahama Y,Caamano JH,Hayday AC,La

    更新日期:2012-03-23 00:00:00

  • Interleukin-23 drives intestinal inflammation through direct activity on T cells.

    abstract::Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, w...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.08.010

    authors: Ahern PP,Schiering C,Buonocore S,McGeachy MJ,Cua DJ,Maloy KJ,Powrie F

    更新日期:2010-08-27 00:00:00

  • Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo.

    abstract::Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic recept...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.02.005

    authors: Lee CS,Penberthy KK,Wheeler KM,Juncadella IJ,Vandenabeele P,Lysiak JJ,Ravichandran KS

    更新日期:2016-04-19 00:00:00

  • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.

    abstract::Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2013.07.008

    authors: Galon J,Angell HK,Bedognetti D,Marincola FM

    更新日期:2013-07-25 00:00:00

  • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

    abstract::T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhanc...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90161-2

    authors: Boise LH,Minn AJ,Noel PJ,June CH,Accavitti MA,Lindsten T,Thompson CB

    更新日期:1995-07-01 00:00:00

  • The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

    abstract::To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00394-1

    authors: Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

    更新日期:2002-09-01 00:00:00