T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

journal_title：Immunity

authors： Laky K,Evans S,Perez-Diez A,Fowlkes BJ

更新日期：2015-01-20 00:00:00

abstract：:Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin...

journal_title：Immunity

authors： Angiari S,Donnarumma T,Rossi B,Dusi S,Pietronigro E,Zenaro E,Della Bianca V,Toffali L,Piacentino G,Budui S,Rennert P,Xiao S,Laudanna C,Casasnovas JM,Kuchroo VK,Constantin G

更新日期：2014-04-17 00:00:00

abstract：:Cdc42 and WASP are critical regulators of actin polymerization whose function during T cell signaling is poorly understood. Using a novel reagent that specifically detects Cdc42-GTP in fixed cells, we found that activated Cdc42 localizes to the T cell:APC contact site in an antigen-dependent manner. TCR signaling alon...

journal_title：Immunity

authors： Cannon JL,Labno CM,Bosco G,Seth A,McGavin MH,Siminovitch KA,Rosen MK,Burkhardt JK

更新日期：2001-08-01 00:00:00

abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

journal_title：Immunity

authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

更新日期：2016-08-16 00:00:00

abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

journal_title：Immunity

authors： Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

更新日期：1999-11-01 00:00:00

abstract：:Differentiation of naive T cells into mature Th2 cells is associated with the appearance of a complex pattern of DNase I hypersensitive (DH) sites within the IL-4/IL-13 cytokine gene cluster. We show here that targeted deletion of an inducible DH site, V(A), and the adjacent conserved DH site V (CNS-2) selectively com...

journal_title：Immunity

authors： Solymar DC,Agarwal S,Bassing CH,Alt FW,Rao A

更新日期：2002-07-01 00:00:00

abstract：:After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fr...

journal_title：Immunity

authors： Liu X,Dai S,Zhu Y,Marrack P,Kappler JW

更新日期：2003-09-01 00:00:00

abstract：:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...

journal_title：Immunity

authors： Gordon S,Martinez FO

更新日期：2010-05-28 00:00:00

abstract：:Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

journal_title：Immunity

authors： Strober W

更新日期：2010-11-24 00:00:00

abstract：:Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which geneti...

journal_title：Immunity

authors： Wakeland EK,Liu K,Graham RR,Behrens TW

更新日期：2001-09-01 00:00:00

abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...

journal_title：Immunity

authors： Conejo-Garcia JR,Rutkowski MR

更新日期：2015-12-15 00:00:00

abstract：:Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...

journal_title：Immunity

authors： Afonina IS,Müller C,Martin SJ,Beyaert R

更新日期：2015-06-16 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...

journal_title：Immunity

authors： Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL

更新日期：2008-12-19 00:00:00

abstract：:Much of the current understanding in hematopoietic stem cell differentiation into immune-cell lineages comes from mouse studies, but how well does it translate to the human system? ...

journal_title：Immunity

authors： Payne KJ,Crooks GM

更新日期：2007-06-01 00:00:00

abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

journal_title：Immunity

authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

更新日期：2000-05-01 00:00:00

abstract：:Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...

journal_title：Immunity

authors： Joshi NS,Akama-Garren EH,Lu Y,Lee DY,Chang GP,Li A,DuPage M,Tammela T,Kerper NR,Farago AF,Robbins R,Crowley DM,Bronson RT,Jacks T

更新日期：2015-09-15 00:00:00

abstract：:In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

journal_title：Immunity

authors： Bowie AG

更新日期：2010-09-24 00:00:00

abstract：:A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...

journal_title：Immunity

authors： Shrikant P,Khoruts A,Mescher MF

更新日期：1999-10-01 00:00:00

abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

journal_title：Immunity

authors： Kuhn JR,Poenie M

更新日期：2002-01-01 00:00:00

abstract：:Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...

journal_title：Immunity

authors： Godec J,Tan Y,Liberzon A,Tamayo P,Bhattacharya S,Butte AJ,Mesirov JP,Haining WN

更新日期：2016-01-19 00:00:00

abstract：:T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transc...

journal_title：Immunity

authors： Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

更新日期：2012-04-20 00:00:00

abstract：:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...

journal_title：Immunity

authors： Zhang X,Sun S,Hwang I,Tough DF,Sprent J

更新日期：1998-05-01 00:00:00

abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...

journal_title：Immunity

authors： Amanat F,Krammer F

更新日期：2020-04-14 00:00:00

abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

journal_title：Immunity

authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

更新日期：2003-08-01 00:00:00

abstract：:Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes...

journal_title：Immunity

authors： Koltsova EK,Grivennikov SI

更新日期：2014-05-15 00:00:00

abstract：:The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...

journal_title：Immunity

authors： Boudreau JE,Liu XR,Zhao Z,Zhang A,Shultz LD,Greiner DL,Dupont B,Hsu KC

更新日期：2016-08-16 00:00:00

abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

journal_title：Immunity

authors： McWhirter SM,Jefferies CA

更新日期：2020-07-14 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are beginning to unravel the difference between the human and preclinical animal response to the antibody. ...

journal_title：Immunity

authors： Schraven B,Kalinke U

更新日期：2008-05-01 00:00:00