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Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein.

Abstract：

:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) immediate-early protein, BZLF1, inhibits the IFN-gamma signaling pathway. BZLF1 decreases the ability of IFN-gamma to activate a variety of important downstream target genes, such as IRF-1, p48, and CIITA, and prevents IFN-gamma-induced class II MHC surface expression. Additionally, BZLF1 inhibits IFN-gamma-induced STAT1 tyrosine phosphorylation and nuclear translocation. Finally, we demonstrate that BZLF1 decreases expression of the IFN-gamma receptor, suggesting a mechanism by which EBV may escape antiviral immune responses during primary infection.

journal_name

Immunity

journal_title

Immunity

authors

Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

doi

10.1016/s1074-7613(01)00226-6

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

787-99

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00226-6

journal_volume

15

pub_type

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